Finerenone is a non-steroidal mineralocorticoid receptor antagonist (MRA) designed to manage heart failure, especially in patients with chronic kidney disease (CKD) and type 2 diabetes. Heart failure and CKD frequently co-exist, and the combination poses a particularly high cardi [....] » Read More
Atherosclerosis has a long preclinical phase and the risk of cardiovascular events may be high in patients in the asymptomatic stage of the disease (subclinical atherosclerosis, SA). The presence of classical risk factors increases the likelihood of developing cardiovascular even [....] » Read More
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The primary prevention of CVD is dependent upon the ability to identify high-risk individuals long before the development of overt events. This highlights the need for accurate risk stratificatio [....] » Read More
Background: Left ventricular systolic function is not well-characterized in patients with low high-sensitivity cardiac troponin I (hs-cTnI) evaluated in the Emergency Department (ED). Methods: A stepped-wedge randomized trial conducted from July 2020 to March 2021, involved pa [....] » Read More
Introduction: Atrial Fibrillation (AF) is the most common sustained arrhythmia, and its incidence and prevalence are growing in the United States and worldwide. Catheter ablation was successful in decreasing recurrence of AF by 48% and symptomatic AF by 51% compared with drug the [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Introduccion: Diabetes is a major comorbidity for heart failure and is more common than myocardial infarction with an increased risk of more than 50% in cardiovascular disease. Recently, high-sensitivity cardiac troponin T (hs-cTnT) has been shown to be associated with the [....] » Read More
Aim of the study: The study is aimed to clear the cycle effect of fear or anxiety and calm or reassurance on electrocardiographic ST-segment depression in patients present with angina with possible coronary artery spasms. Background: Anxiety and fear have undoubted hazardous e [....] » Read More
This retrospective cohort study aimed to compare the one-year outcomes of anterior-posterior (AP) and anterior-lateral (AL) methods of cardioversion for atrial fibrillation (AF). A total of 2168 patients were included, with 1125 patients in the AP cardioversion group (Group 1) an [....] » Read More
Purpose: Transgenders are the most neglected population in South Asia especially in Pakistan. Before 2018 they do not have any rights and privileges. The first study was planned to investigate the effects of high-intensity circuit training on cardiometabolic and cardiorespiratory [....] » Read More
Background: This study aimed to examine the longitudinal association between the triglyceride glucose-body mass index (TyG-BMI) index and memory-related diseases (MDs) among Chinese adults. Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CH [....] » Read More
Cardiac rhabdomyoma is a hamartoma comprised of cardiac myocytes. It is most commonly diagnosed in infancy, 70 to 90% of whom have TSC (Tuberous sclerosis complex). It usually shows spontaneous regression within the first two years of life and hence is extremely rare in adults. I [....] » Read More
Background: Cardiovascular disease risk assessment tools are algorithms used to predict an individual’s chance of developing a cardiovascular disease within a specific period. It has been shown that awareness of one’s risk of developing a particular disease often resu [....] » Read More
Background: While hyperthyroidism and atrial fibrillation has been extensively studied, in patients with atrial fibrillation, much remains unexplored regarding the presence of concurrent subclinical hypothyroidism and in-hospital outcomes. We will explore the national inpatient s [....] » Read More
Introduction: Constrictive pericarditis is a rare disease where calcification of the pericardium leads to restricted diastolic filling of the heart. Due to its non-specific symptoms, such as dyspnea with exertion, peripheral edema, and chest discomfort, it can mimic many primary [....] » Read More
Introduction: Mucous membrane pemphigoid (MMP) is a rare, chronic, autoimmune disease presenting with subepithelial blistering and erosive lesions on the mucosal surface of the mouth, eyes, and occasionally the pharynx. While initial treatment of mild pemphigoid of the oral cavit [....] » Read More
Background: Aortic stenosis (AS) is a progressive condition with high morbidity and mortality if left untreated. Currently, there are clinical guidelines to help provide physicians with recommendations for clinical decisions. Class 2 guidelines have inherently weaker evidenc [....] » Read More
Background: Heart failure education is crucial for improving patient outcomes, yet barriers persist due to varying levels of health literacy. Patients with lower literacy often struggle with understanding complex medical concepts, impairing medication adherence and disease m [....] » Read More
Introduction: Current treatment recommendations for secondary mitral regurgitation (MR) include transcatheter edge-to-edge repair (TEER) and mitral valve surgery. Surgical repair (SR) has been the traditional approach but TEER has emerged as a less invasive alternative. Currently [....] » Read More
Introduction: Tricuspid regurgitation (TR) is a common valvular disease linked to significant morbidity and mortality. It has a well-documented independent prognostic impact. Surgical repair (SR) is a recognized option for severe or progressive TR, or as an adjunct to mitral valv [....] » Read More
Spironolactone belongs to the second class of the bio pharmacy classification system (BCS). All of the drugs, which are classified in this group, suffer from the solubility as the major problem. For this reason, application of any different technique which increases the solubilit [....] » Read More
Title : Novel important cellular responses, signaling mechanisms and therapeutic options for pulmonary hypertension and right heart failure
Yong Xiao Wang, Albany Medical Center, United States
As a common and devastating lung disease, pulmonary hypertension (PH) has a significant rate of both morbidity and death mortality. The current primary interventions for this disease are to use non-specific vasodilators, but patients do not always respond well to these non-specif [....] » Read More
Title : Preventing sports-related cardiac arrest: Coronary artery calcium scoring stratifies the benefit of low-dose aspirin use for risk reduction
Arthur J Siegel, Massachusetts General Hospital, United States
While habitual endurance exercise such as training for a marathon is quintessentially cardioprotective, running such a race paradoxically confers a transiently increased risk for cardiac arrest and sudden death. The frequency of such events increased significantly in United State [....] » Read More
Title : TED2HOME - A low cost automatic external defibrillator for home/office
Abraham Teddy Weiss, Hadassah University Hospital, Israel
Sudden cardiac death (SCD)-caused by ventricular fibrillation (VF) or standstill-is one of the biggest unmet need in public health: it is unpredictable and occurs in about 1000 persons/day in US and Europe alone with very poor survival. Since survival drops by 10% for every minut [....] » Read More
Title : The low grade chronic inflammation and atherosclerosis
Sekib Sokolovic, Sarajevo University Clinical Center, Bosnia and Herzegowina
Introduction: The low grade chronic inflammation (LCGI) is response to the underlying disorders, injuries, antigen and is result of the failure to acute infection, viruses, tuberculosis, protozoa, fungal and foreign material. The risk factor of LCGI are smoking, obesity, hi [....] » Read More
Title : The development of human relaxin-2 for heart failure with preserved ejection fraction, HFpEF
Thomas Bernd Dschietzig, Relaxera GmbH & Co. KG, Germany
Human relaxin-2 (hRlx-2) is a hormone of pregnancy that has engendered a great deal of interest as a therapy for various cardiovascular and inflammatory diseases, among them Acute Heart Failure and Systemic Scleroderma. Here, we propose and summarize data showing that Rlx-2 repre [....] » Read More
Title : Empathy and precision: Revolutionizing communication between cardiologists and patients
Iris Panagiota Efthymiou, University of Greenwich, United Kingdom
Effective communication is critical in cardiology, where the stakes often involve life-altering decisions. This presentation explores the intersection of empathy and precision in communication, emphasizing the cardiologist’s role in fostering trust, understanding, and patie [....] » Read More
Title : Ex-situ organ perfusion and cardiac performance improvement
Y J H J Taverne, Erasmus University Medical Center, Netherlands
Cardiac transplantation remains the golden standard for patients with end-stage heart failure when therapeutic approaches and interventions fail to reverse HF progression. Traditionally, hearts are transplanted from brain-death (DBD) donors where the heart is beating at time of p [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through biodesign-driven and inspired biotech, translational applications and cardiology-related marketing to secure the human healthcare, wellness and biosafety
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogni [....] » Read More
Title : Doppler ultrasound measurement of arterial stiffness
Trevor Tucker, T Tucker Inc, Canada
The stiffening of arteries has been widely recognized as a major contributor to cardiovascular diseases and all cause mortality. Arterial stiffening has significant association with arteriosclerosis and atherosclerosis development. In spite of the world-wide recognition, arterial [....] » Read More
Title : Impact of depression and cardiovascular risk factors on cognitive impairment in patients with atrial fibrillation: A systematic review and meta-analysis
Maria Del Pino, Houston Methodist Hospital, United States
Background: Atrial fibrillation (AF) is a common cardiac arrhythmia associated with significant cardiovascular morbidity and mortality, as well as cognitive impairment (CI). The interplay between AF and CI is complex, involving various pathophysiological changes and numerous risk [....] » Read More
Title : Heart of stone: A rare case of incidentally detected endocardial calcification
Vaibhav Sharma, St. Louis Heart and Vascular, United States
Background: Endocardial calcification is a rare cardiac condition with limited documented cases, particularly in non-tropical regions. This case report explores an unusual presentation of incidental endomyocardial calcification in a patient without typical predisposing systemic d [....] » Read More
Title : Green alert: Myocardial infarction triggered by marijuana use
Vaibhav Sharma, St. Louis Heart and Vascular, United States
Background: The cardiovascular implications of marijuana use have gained increasing attention in recent medical literature. While chronic cannabis consumption has been linked to various cardiovascular events, comprehensive documentation of acute myocardial infarction in young adu [....] » Read More
Title : Minimal invasive pediatric and adult congenital cardiac surgery
Y J H J Taverne, Erasmus University Medical Center, Netherlands
Full midline sternotomy remains the most common incision to correct congenital cardiac defects. Although many minimal invasive programs exist for the adult population worldwide, only a few centers have adopted such a program for the pediatric population. The rise of novel interve [....] » Read More
Title : Miniaturized living myocardial slices derived from pediatric tetralogy of fallot specimens: A novel platform for investigating contractile performance and pharmacological interventions
Ziyu Zhou, Erasmus University Medical Center, Netherlands
Congenital heart disease (CHD) continues to pose significant challenges in paediatric cardiology, and Tetralogy of Fallot (ToF) stands out as a condition in need of improved translational models. Traditional in vitro and animal-based systems provide valuable insights but often fa [....] » Read More
Title : Smoking status and early vascular aging: How to reduce cardiovascular risk at the current stage of knowledge?
Aleksandr Filippov, St. Petersburg State University, Russian Federation
Background: Smoking status (SS) is associated with structural and functional vascular changes which may lead to increased arterial stiffness and, as a consequence, the formation of early vascular aging. The purpose of this study was to investigate the relationship betwe [....] » Read More
Title : The promising future of the unique translational tool to manage self-renewal of cardiac cells and to support regeneration in the post-infarction period
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
The approaches securing cardiac regeneration in post-infarction period are not available to be practiced. The key problem is the identity of cells be born to generate functionally active cardiac myocytes replenishing those being lost during ischemia. With identification of reside [....] » Read More
Title : Multiple cerebral infarcts caused by left ventricular thrombus: A multidisciplinary challenge
Sara Ismail Abdelhalim Ismail, Al-Sabah Hospital-Medical, Kuwait
Introduction: Left ventricular (LV) thrombus accounts for up to 10% of cardioembolic strokes. It is frequently observed in patients with a history of myocardial infarction, particularly those with anterior STEMI, reduced left ventricular ejection fraction (LVEF), non-ischemic car [....] » Read More
Title : Microbial diversity drives metabolic alterations and disrupts functional pathways in acute myocardial infarction: Evidence from three distinct microbiotic compartments
Ikram Khan, Lanzhou University, China
Our study investigates the interplay between the microbiome and metabolome in acute myocardial infarction (AMI), focusing on the diagnostic potential of blood, gut, and oral microbiota and their metabolomic signatures. Blood, fecal, and saliva samples from AMI patients and health [....] » Read More
Title : Seizure-like episode unmasking torsade’s de pointes: A rare presentation of an arrhythmic emergency
Kanchan Kanchan, Birmingham Heartlands Hospital, United Kingdom
We present the case of a 40-year-old male who experienced a seizure-like episode, later diagnosed as torsade's de pointes (TDP), highlighting the diagnostic and management challenges of this atypical presentation. The episode characterized by generalized shaking without tongu [....] » Read More
Title : First data on putative baroreceptors in human aorta and aortic arch
Yankey Yundung, University Hospital Zurich, Switzerland
The baroreflex is a key mechanism for regulating blood pressure and heartbeat, mediated by mechanosensitive baroreceptors. The entire knowledge on baroreceptors, however, has been derived predominantly from animal studies. No data focusing on the molecular nature of the human aor [....] » Read More
Title : Left atrioventricular coupling index as a novel prognostic marker of adverse events in heart transplant patients
Chun Wu, Huazhong University of Science and Technology, China
Purpose: Decreased diastolic(DD) function may be one of the early manifestations of acute rejection after heart transplantation. Left atrioventricular coupling index (LACl) is associated with DD severity. The purpose of this study was to investigate the novel prognostic value of [....] » Read More
Title : The impact of platelet/lymphocyte ratio and white blood cell/lymphocyte ratio on the prognosis of patients with acute ST segment elevation myocardial infarction undergoing PCI during hospitalization
Yanmin Xu, Tianjin Medical University Second Hospital, China
Objective: The platelet-to-lymphocyte ratio (PLR) and white blood cell to lymphocyte ratio (WLR) are potential markers of inflammation. This study aimed to investigate the relationship between PLR, WLR, and the risk of major adverse cardiovascular events (MACE) in patients w [....] » Read More
Title : Caught in a red and blue squeeze: A plaque-free coronary crisis
Zoya Khan, Lakeland Regional Health, United States
Introduction: Anomalous origin of the right coronary artery (RCA) is a rare congenital condition, accounting for less than 1% of coronary anomalies. While many patients are asymptomatic, the anomalous course can lead to myocardial ischemia through external compression rather than [....] » Read More
Title : A waiting game: The risky business of repairing a friable septum
Michael Sabina, Lakeland Regional Health Medical Center, United States
This presentation will focus on the critical and complex decision-making process involved in managing ventricular septal defects (VSDs) that develop after myocardial infarction (MI). Although VSDs following MI are rare, they represent a life-threatening complication with a high m [....] » Read More
Title : Enhancing maternal and fetal outcomes: The role of routine antenatal echocardiography in high-prevalence areas of rheumatic heart disease
Malik Takreem Ahmad, King’s College London, United Kingdom
Background: Rheumatic heart disease (RHD) is a leading cause of valvular heart disease globally, particularly in low- and middle-income countries, where it significantly contributes to non-obstetric maternal morbidity and mortality. Echocardiography has emerged as a promising too [....] » Read More
Title : Epoprostenol infusion in pulmonary hypertension: A case of mechanical complication and management
Ali Elshamy, Northampton General Hospital, United Kingdom
Introduction: Pulmonary hypertension is a chronic progressive disease characterized by raised pulmonary vascular resistance ultimately leading to right sided heart failure. Amongst the current available options for treatment, Epoprostenol has been widely proven to improve sy [....] » Read More
Title : Clinical profile of acute coronary syndrome in the elderly in a peripheral health center
Raghul Ganesapandi, Director Cath Lab J. P Heart Institute, India
Background: Age is a key factor influencing outcomes for patients with acute coronary syndromes (ACS). However, in community practice, there is a noticeably lower utilization of cardiovascular medications and invasive treatments among elderly patients with ACS, even though t [....] » Read More
Title : Transient ST-elevation MI diagnosed by holter monitoring
Nabihah Hussaini, University Hospital Lewisham, United Kingdom
Presentation: A 54-year-old woman was referred with an 8-week history of pressure sensations over the chest and epigastrium unrelated to exertion. She presented to the Emergency Department 4 weeks prior but self-discharged against medical advice due to the long wait time. Diag [....] » Read More
Title : Immediate recoil after percutaneous balloon angioplasty of below the knee arteries in patients with critical limb ischemia
Farrukh Malik, National institute of cardiovascular diseases, Pakistan
Introduction: Chronic limb ischemia (CLI), the terminal manifestation of peripheral artery disease, has an estimated prevalence of 6.5 million in the United States and Japan, with an annual incidence of 2.3% per year. Patients diagnosed with CLI have a 1-year mortality rate of ap [....] » Read More
Title : Cannabis abuse and ST segment elevation ACS
Farrukh Malik, National institute of cardiovascular diseases, Pakistan
Introduction: Coronary artery disease (CAD) is primarily influenced by modifiable risk factors including smoking. Smoking Cannabis is one of the most widely used illicit substances worldwide, which is on the rise due to legalization in different parts of the world, and it ha [....] » Read More