Title : The low grade chronic inflammation and atherosclerosis
Abstract:
Introduction: The low grade chronic inflammation (LCGI) is response to the underlying disorders, injuries, antigen and is result of the failure to acute infection, viruses, tuberculosis, protozoa, fungal and foreign material. The risk factor of LCGI are smoking, obesity, high salt diet, stress, lack of sleep, sedentary lifestyle, alcohol, dental impairment, mild chronic infections etc. Laboratory tests reveal slighty increased non-specific parameters of inflammation like hs-CRP, amyloid, fibrinogen, polyclonal gammopathy, hypoalbuminemia, proinflammatory cytokines, increased volume of platelets (MVP) and low sera vitamin D. MVP may be considered as an inflammatory marker of LCGI. In obese patients with a glucose intolerance and metabolic synrome there is high level of pro-inflammatory cytokines, insulin resistance, hyperinsulinemia, the propagation of atherosclerosis through the leucocyte activation, altered macrophage and endothelial adhesion molecules expression. The LCGI is the main feature of post-covid and fatigue is a typical clinical manifestation. The efficiancy of colhicine is the evidence of hypothesis.
Objective: To emphasize the relation of LCGI and atherosclerosis responsible for the increased morbidity and mortality.
Material: The review evidence based scientific material, expert oppinion and personal expirience.
Conclusion: The LCGI plays a key role in atherosclerosis , metabolic and other disorders. Although there is no specific biomarkers recognized, the relationship between inflammation and atherosclerosis may be outlined by non-specific laboratory inflammatory markers. Treatment of advanced atherosclerosis should include anti-inflammatory properties.
