Sudden cardiac death (SCD) among athletes has been increased in recent years. This high-impact event occurs from unrecognized structural or electrical heart disease in professional athletes, while in recreational sports happens in older athletes due to occult coronary artery dise [....] » Read More
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). In this context, the need for innovative heart disease treatments has become critical since the diseases remain the world&r [....] » Read More
Objective The C-Reactive protein-triglyceride glucose index (CTI) serves as a dependable proxy for both inflammatory status and insulin resistance, demonstrating an independent association with various clinical presentations of coronary artery disease. This research sought to ass [....] » Read More
Background The current cardiovascular risk assessment system has not fully integrated the interaction between atherosclerotic promoting factors and protective factors. Lipoprotein(a) [Lp(a)], an independent risk factor for coronary heart disease, has a pathogenic risk that may be [....] » Read More
Background: Guidelines recommend patent foramen ovale (PFO) closure for secondary prevention after cryptogenic stroke in patients aged 18-65 years, but there is limited evidence to guide management of older adults. This research aims to assess the efficacy, safety and methodologi [....] » Read More
BACKGROUND: The hyperproliferation of smooth muscle cells and deposition of collagen in the pulmonary artery are among the primary characteristics of pulmonary hypertension (PH). These processes contribute to vascular remodeling, ultimately leading to elevated pulmonary artery pr [....] » Read More
Background: Coronary artery disease remains a leading cause of global mortality. Although angiography-guided percutaneous coronary intervention (PCI) is the standard approach, it has limitations in visualizing plaque morphology, vascular remodeling, atherosclerotic burden, and ca [....] » Read More
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) remain significant causes of pediatric morbidity in low-resource settings. Local data on clinical profiles and outcomes in the Philippines remain limited, underscoring the need for updated institutional evidence. This [....] » Read More
Background: AL (light-chain) amyloidosis is a rare multisystem disorder caused by extracellular deposition of monoclonal immunoglobulin light chains, leading to progressive organ dysfunction. Cardiac involvement is the strongest predictor of mortality and often presents with [....] » Read More
Objectives: To determine the frequency and identify the determinants of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography and/or percutaneous coronary intervention (PCI) in a tertiary care hospital in rural Pakistan. Methodology: This [....] » Read More
Post COVID-19 pulmonary assessment revealed a persistent decrease in maximal oxygen consumption (VO? max) among previously symptomatic individuals. A proportion of patients particularly those with severe disease or ARDS exhibited reduced diffusion capacity for carbon monoxide (DL [....] » Read More
Heart care is changing fast. New devices and digital tools are improving how we diagnose and treat heart disease. Combination products are also becoming more common. These innovations bring real hope to patients. But they also create regulatory challenges. Many promising technol [....] » Read More
The incidence of cardiovascular diseases (CVDs) has greatly risen in recent years because of environmental shifts, unhealthy diets, and changes in lifestyle. Consequently, the term "hridroga," which pertains to heart-related ailments in Ayurveda, has gained prominence. [....] » Read More
The individual risk profile of the patient and the health added value of the interventions define the affordability of health care. 1. The re-allocation of resources guarantees the financial viability of healthcare. 2. Re-allocation is based on evidence of objective proof o [....] » Read More
Sickle cell disease and thalassemia syndromes are increasingly recognized as chronic multisystem disorders, with cardiovascular (CV) sequelae representing a significant proportion of long-term morbidity and mortality. Survival has improved considerably due to the better transfusi [....] » Read More
Background: Polysplenia syndrome, a rare form of left isomerism, usually presents in childhood with severe cardiac anomalies. Adult presentation with a structurally normal heart is uncommon. Case Presentation: A 26-year-old male presented with recurrent syncope over one year. [....] » Read More
The lymphatic system is a fundamental yet underrecognized component of cardiovascular regulation, immune homeostasis, and metabolic balance. Lymphatic dysfunction contributes to chronic inflammation, endothelial impairment, venous hypertension, and interstitial fluid overload, th [....] » Read More
Rationale: Diagnosis of ST-segment elevation myocardial infarction in the presence of left bundle branch block (LBBB) is challenging and infarction equivalent. Therefore, the intravenous infusion of a thrombolytic may be a crucial step. Emergent Sgarbosa criteria and their modifi [....] » Read More
Background: Type 1 diabetes (T1D) is rising globally, with a disproportionate burden of complications in developing countries. In such settings, a 10-year-old diagnosed with T1D has an average life expectancy of only 13 years, five times lower than in high-income countries. Adver [....] » Read More
Background: N-terminal pro-B type natriuretic peptide (NT-proBNP) has been introduced as a useful parameter for assessing left ventricular (LV) function. We aimed to evaluate correlation between NT proBNP on the LV systolic and diastolic echocardiographic parameters in mid-range [....] » Read More
Background: Prolonged corrected QT (QTc) interval is associated with an increased risk of cardiovascular mortality and sudden cardiac death. We sought to investigate whether 24-hour (h) ambulatory blood pressure (ABP) profiles and echocardiographic findings with QTc prolongation [....] » Read More
In 2026, artificial intelligence (AI) has emerged as an indispensable co-pilot in cardiology, fundamentally transforming the management of cardiovascular diseases through enhanced precision diagnosis, optimized clinical trials, and proactive prevention strategies. The rapid integ [....] » Read More
Dilated cardiomyopathy (DCM) is one of the most important causes of heart failure and premature death globally, yet its burden is far from uniform. In developing nations—where diagnosis is often delayed, access to specialized cardiac care is limited, and multiple overlappin [....] » Read More
Heterotaxy syndrome is a rare congenital disorder characterized by abnormal arrangement of thoracoabdominal organs and complex cardiovascular malformations. Left isomerism, a subtype, typically features bilateral left atrial appendages, polysplenia, and interrupted inferior vena [....] » Read More
In our review, we wanted to highlight the advantages of implanting cardiac pacemakers on the right side of the chest, with the generator site below the right clavicle. This approach is not used as often as a method of implanting cardiac pacemakers today, but it has its advantages [....] » Read More
Background: Atrial Septal Defects (ASDs) are common congenital heart defects, affecting nearly 25% of children. Larger ASDs may require device closure to prevent complications such as pulmonary hypertension and hypoxia. Evidence on long-term outcomes and adverse events after clos [....] » Read More
This case study integrates the relationship between connective tissue dysfunction and the formation of aortic aneurysms, emphasizing the molecular basis and its clinical expression. These types of disorders, mainly represented by Marfan and Loeys-Dietz syndromes, are he [....] » Read More
Background: Ventricular premature complex (VPC) is one of the most common ventricular arrhythmias and is strongly associated with heart failure (HF), all-cause hospitalization, and cardiovascular hospitalization Patients and Methods: Fifty-eight patients with ventricular extra [....] » Read More
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a cornerstone in managing type 2 diabetes (T2D) and obesity, demonstrating benefits that extend far beyond glycaemic control. Initially developed for metabolic regulation, several large-scale cardiovascular out [....] » Read More
Diabetes Mellitus (DM) has become a global epidemic. Its prevalence is increasing and is becoming younger among adults. Although type 2 diabetes accounts for the majority of diabetes, type 1 diabetes is also increasing. Patients with DM often have complex coronary anatomy, compli [....] » Read More
Title: Beyond Mechanical Revascularization: Intra-Plaque Integration of Nanoparticle-Coated PCSK9 Inhibitors, DMARDs, and APOC-3 siRNA as a Synergistic Triple-Target Strategy for Vulnerable Plaque Stabilization Background: Despite the success of percutaneous coronary interv [....] » Read More
Title: Beyond the Horizon: TIGR-Tas In Vivo Gene Editing Utilizing microRNA and Non-Coding RNA for No-Option Terminal Heart Failure Background: Patients with terminal heart failure who have failed pharmacological therapy and mechanical circulatory support (ICD, LVAD, CRT-D) [....] » Read More
INTRODUCTION: Hereditary Hemorrhagic Telangiectasia (HHT) is a rare autosomal dominant vascular disorder characterized by mucocutaneous telangiectasia and arteriovenous malformations (AVMs). Pulmonary arterial hypertension (PAH) is an uncommon manifestation with an aggressive cou [....] » Read More
Introduction: Infective Endocarditis affecting the Mitral-Aortic Inter-valvular Fibrosa (MAIF) is uncommon but clinically significant, as its avascular nature and subtle imaging features frequently lead to delayed recognition. Case Report: A 47-year-old hyp [....] » Read More
Introduction Stent loss during percutaneous coronary intervention (PCI) is a rare but serious complication, particularly in primary PCI where thrombus burden, vessel tortuosity, and suboptimal lesion preparation increase procedural risk. Embolized stents can cause major vascul [....] » Read More
Chronic pain is associated with the leading cause of disability in the world, just as cardiovascular diseases represent the highest incidence of death in the world. Both pathologies generate a high demand for health services and represent a high global population risk. In previou [....] » Read More
A decrease in erythrocyte electrophoretic mobility serves as an important diagnostic marker of pathological conditions associated with impaired gas exchange, microcirculation, and tissue trophism, often leading to systemic hypoxia and deterioration of the patient's clinical s [....] » Read More
Purpose: The objective of this study was to assess differences in dietary behavior and clinical risk factor outcomes and explore predictors of change among patients participating in traditional and Pritikin intensive cardiac rehabilitation (CR). Methods: This secondary a [....] » Read More
Valvular heart disease (VHD) remains a major and growing cause of cardiovascular morbidity and mortality, particularly in ageing populations. The recent ESC/EACTS 2025 Guidelines provide an updated, evidence-based framework for the diagnosis, risk stratification, and management o [....] » Read More
This keynote highlights how movement as medicine supports the goals of the Cardiology World Conference 2026 by emphasizing innovative, preventive approaches to heart health. For cardiologists, cardiovascular surgeons, researchers, healthcare practitioners, academicians, industry [....] » Read More
Background: Thyrotoxic periodic paralysis (TPP) is a rare but potentially fatal manifestation of hyperthyroidism characterized by sudden hypokalemic paralysis. Excess thyroid hormone stimulates the Na?/K?-ATPase pump, causing rapid intracellular potassium shifts and severe hypok [....] » Read More
This study evaluates the impact of the recently developed BSSI on diabetic adults in Pakistan. A comparative analysis was conducted between BSSI, body mass index (BMI), and body surface area (BSA) to assess the performance of BSSI and identify ideal measures that can accurately p [....] » Read More
Establishing growth charts is one of the most important steps in establishing normal development standards and identifying possible patterns in human growth. The purpose of this study is to examine how well body surface area (BSA) and quantile regression (QR) percentiles perform [....] » Read More
Title : Preservation of Skeletal Muscle Mass During GLP 1 Receptor Agonist Mediated Weight Loss Clinical Determinants Risk Stratification and Evidence Based Mitigation Strategies
Narendra Kumar, HeartbeatsZ Academy, United Kingdom
Background and rationale. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including semaglutide and tirzepatide, consistently achieve 10–22% total body weight reduction in clinical trial populations; however, cross-sectional and longitudinal data increasingly dem [....] » Read More
Title : STEMI versus acute occlusive myocardial infarction: Which term should we use?
Yochai Birnbaum, Baylor College of Medicine, United States
The original trials assessing the effects of thrombolytic therapy versus placebo included patients with compatible symptoms and were not restricted to patients with ST elevation. However, a meta-analysis that was published in Lancet in 1996 suggested that thrombolytic therapy red [....] » Read More
Title : New mechanisms and innovative therapeutics for pulmonary hypertension
Yong Xiao Wang, Albany Medical Center, United States
Pulmonary hypertension (PH) is a common and serious lung disease, molecular mechanisms remain poorly understanded, and medications are neither always effective nor specific. In a series of our current studies, we have explored the potential important role of ryanodine receptor 2 [....] » Read More
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, Massachusetts General Hospital, United States
Advances in primary cardiovascular prevention depend upon enhanced risk stratification. Gated coronary artery calcium CT scanning independently identifies persons at increased risk for major acute cardiac events including sudden death due to subclinical coronary atherosclerosis.& [....] » Read More
Title : Outcome of Late Percutaneous Coronary Revascularization versus Optimum Medical Management in Acute ST-Elevation Myocardial Infarction
Md Aminul Haque, Combined Military Hospital (CMH), Bangladesh
Background: Early revascularization is the cornerstone of management in ST-elevation myocardial infarction (STEMI), yet a substantial proportion of patients in resource-limited settings present beyond 24 hours, where the benefit of late percutaneous coronary intervention (PCI) re [....] » Read More
Title : Rare Cardiovascular Diseases Encountered of Pediatric Cardiac Surgery And Cardiology.
Sarsenbaeva Gulzhan, Institute of Surgery, Kazakhstan
In domestic cardiac surgery, there is currently a trend towards an increasing incidence of complex, combined, and rare pathologies of the heart and blood vessels in children. The purpose of the report : to study rare congenital heart anomalies encountered in pediatric cardiac [....] » Read More
Title : The mirrored heart: Chronic troponin elevation beyond obstructive coronary disease in situs inversus totalis
Nguyen Nhat Dinh Ngo, Hoan My Sai Gon Hospital, Vietnam
Background Situs inversus totalis is a rare congenital anomaly that poses unique challenges in electrocardiographic interpretation and the assessment of myocardial ischemia. While cardiac troponin elevation is commonly indicative of myocardial injury due to obstructive coronar [....] » Read More
Title : Hierarchical Multi-Instance Learning for Automated Screening and Subtype Classification of Congenital Heart Disease From Echocardiography Videos
Peipei Zhang, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, China
Background: Transthoracic echocardiography is the first-line test for congenital heart disease (CHD), but accurate screening and lesion subtyping require expertise and synthesis across multiple heterogeneous cine clips. We developed a video-based deep learning approach for examin [....] » Read More
Title : Prognostic Value of Twelve Systemic Inflammatory Indices for Composite Cardiovascular Events in Chronic Coronary Syndrome Patients With or Without Diabetes Undergoing PCI
Longcheng Liu, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China
Background: Inflammation is widely recognized as a central contributor to the pathogenesis and prognosis of repeat revascularization (RR) and in-stent restenosis (ISR) following percutaneous coronary intervention (PCI). Diabetes mellitus (DM) not only markedly increases the risk [....] » Read More
Title : Community Based Approaches to Preventing Cardiovascular Diseases in Developing Countries
kwabena Sakyi, Ghana Standards Authority, Ghana
Cardiovascular diseases remain one of the leading causes of death worldwide, with a growing burden in developing countries where access to specialized cardiac care is limited. This presentation explores the role of community-based interventions in improving heart health [....] » Read More
Title : Seconds to act: Advancing community cardiac arrest survival through AED access and bystander activation
Joseph W Ellis, American Whitewater Expeditions, United States
Sudden Cardiac Arrest (SCA) is a leading cause of preventable death globally, with survival declining 7–10% for every minute defibrillation is delayed. While advances in emergency medicine have improved outcomes, the first moments following an arrest remain critical—a [....] » Read More
Title : A unique cell-driven phenomenon in the heart and the promising future of the innovative translational tools to manage cardiac self-renewal and regeneration
Sergey Suchkov, N. D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Stem cell (SC)-based therapy has been considered as a promising option in the treatment of ischemic heart disease. The formation of new cardiomyocytes within the injured myocardium has not been conclusively demonstrated. Consequently, the focus of research in the field has since [....] » Read More
Title : Diagnosis and treatment of primary cardiac lymphoma in an immunocompetent 27 year old man
Moataz Taha Mahmoud, Madinah Cardiac Center, Saudi Arabia
Background: Primary cardiac lymphomas (PCL) represent extremely rare cardiac tumors which are accompanied by poor prognosis, unless they are timely diagnosed and treated. Despite the rarity of Primary cardiac lymphomas, they should always be kept in mind in the differential diagn [....] » Read More
Title : Predicting immune checkpoint inhibitor cardiotoxicity using machine learning: A systematic review of model performance and methodological quality
Vaibhav Roy, Sharda University, India
Background: Immune checkpoint inhibitors (ICIs) significantly improve cancer outcomes but can cause rare, potentially fatal cardiotoxicity, including myocarditis and major adverse cardiovascular events (MACE). Machine learning (ML) and artificial intelligence (AI) models have eme [....] » Read More
Title : Enhancing recovery: Quality of life changes measured through SF-12 in patients undergoing cardiac rehabilitation in a Colombian specialized center
Diana Carolina Alvarado Echeona, Universidad El Bosque, Colombia
Background: Cardiovascular disease remains a leading cause of disability worldwide, and cardiac rehabilitation (CR) programs play a crucial role in improving physical capacity, risk factor control, and overall patient well-being. However, evidence on short-term changes in health- [....] » Read More
Title : Right ventricular hydatid cyst in a young adult: A rare case from the UAE
Khalid Elhaj Mohamed Saeed, Abu Dhabi Health Services Company (SEHA), United Arab Emirates
Background: Cystic echinococcosis, or hydatid cystic disease, is a globally prevalent zoonotic infection that typically affects the liver or lungs. Case Summary: A 28-year-old man residing in the UAE presented with chronic hemoptysis, melena, and weight loss. Chest radiography [....] » Read More
Title : Association of the Uric Acid-to-Albumin Ratio with Angiographic Severity of Coronary Artery Disease in Patients Undergoing Elective Coronary Angiography
Cassandra Elize P Flores, Veterans Memorial Medical Center, Philippines
The uric acid-to-albumin ratio (UAR) has been proposed as a composite biomarker reflecting inflammatory and oxidative pathways relevant to coronary artery disease (CAD).¹?² Prior studies have explored its association with CAD extent and cardiovascular disease.³?? T [....] » Read More
Title : An Unusual Cause of RV Failure in a Geriatric Patient: Partial Anomalous Pulmonary Venous Drainage
Meiza Azzahra, Dr Soehadi Prijonegoro General Hospital, Indonesia
Background: Partial anomalous pulmonary venous drainage (PAPVD) is a rare congenital cardiovascular anomaly causing left-to-right shunting that may result in chronic right ventricular (RV) volume overload and pulmonary hypertension. Although commonly diagnosed in childhood, pa [....] » Read More
Title : Benign Tumor, Malignant ECG: Isolated Cardiac Rhabdomyoma With Marked ST-Segment Elevation
Devshankar Moosad EI, Christian Medical College, India
Background: Cardiac rhabdomyoma is the most common primary cardiac tumor in infancy and is frequently associated with tuberous sclerosis complex (TSC). Case Summary: A 5-month-old asymptomatic infant presented with electrocardiography (ECG) showing marked ST-segment elevatio [....] » Read More
Title : Management conundrum of right ventricular failure in a mixed connective tissue disease overlap syndrome of systemic lupus erythematosus and systemic sclerosis
Moganapriya, Tan Tock Seng Hospital, Singapore
A 36-year-old woman with a significant history of Group 1 pulmonary arterial hypertension (PAH) with secondary to mixed connective tissue disease overlap syndrome (systemic lupus erythematosus and systemic sclerosis), presented with a one-week history of fever, nonproductive c [....] » Read More
Title : Importance of knowing and maintaining arterial stiffness in cardiovascular health: A report
Snehasis Bhunia, Uttar Pradesh University of Medical Sciences, India
Arterial stiffness is a measure of how flexible and pliable the walls of the arteries are. It is an important indicator of cardiovascular health, as stiff arteries can lead to increased risk of developing cardiovascular diseases such as heart attack and stroke. One of the main f [....] » Read More
Title : Successful isolation of right Accessory pulmonary veins using a variable-loop pulsed-field ablation catheter
Eric Tran, University of California - Riverside, United States
Background: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation for AF and is dependent on achieving durable electrical isolation of all pulmonary veins (PVs). Anatomical variations, such accessory PVs, are common and can lead to incomplete isolation and arrhyt [....] » Read More
Title : A case of sepsis-induced Takotsubo cardiomyopathy precipitating torsades de pointes
Eric Tran, University of California - Riverside, United States
Background: Takotsubo cardiomyopathy (TCM) is a state of left ventricular (LV) dysfunction induced by a hypercatecholaminergic milieu, leading classically to apical dyskinesis with a compensatory hyperdynamic base. We present a case of sepsis-induced TCM complicated by torsades d [....] » Read More
Title : Predictors of post-operative complications in patients following cardiac surgery: A prospective observational study
Esha Mohamed Nisarahmed , M S Ramaiah University Of Applied Sciences, India
Introduction: Cardiac surgery remains a vital intervention for severe cardiovascular conditions. Despite advancements in surgical expertise and technology, postoperative complications—ranging from metabolic and hematologic disturbances to cardiovascular dysregulation— [....] » Read More
Title : Optimizing cardiac safety in contemporary procedures: A multimodal framework for risk stratification, surveillance, and intervention
Abel Don Palayoor , M.S Ramaiah University of Applied Sciences, India
Background: Cardiac complications remain a major source of perioperative morbidity and long-term dysfunction across modern cardiothoracic and interventional procedures. Despite advances in imaging, anaesthesia, and device technology, procedural cardiac risk is amplified by patien [....] » Read More
Title : Role of stress echocardiography with dipyridamol in the diagnosis of myocardial ischemia by evaluation of coronary flow reserve
Faiza Bekakchi, Chu Setif, Algeria
Introduction: Myocardial ischemia is a major cause of cardiovascular morbidity and mortality, Early diagnosis is essential to optimize treatment and improve the prognosis, Stress echocardiography with dipyridamole, in particular the evaluation of coronary flow reserve, constitute [....] » Read More