Arthur J Siegel, Massachusetts General Hospital, United States
While habitual endurance exercise such as training for a marathon is quintessentially cardioprotective, running such a race paradoxically confers a transiently increased risk for cardiac arrest and sudden death. The frequency of such events increased significantly in United State [....] » Read More
Title : Novel important cellular responses, signaling mechanisms and therapeutic options for pulmonary hypertension and right heart failure
Yong Xiao Wang, Albany Medical Center, United States
As a common and devastating lung disease, pulmonary hypertension (PH) has a significant rate of both morbidity and death mortality. The current primary interventions for this disease are to use non-specific vasodilators, but patients do not always respond well to these non-specif [....] » Read More
Title : The past, present and future of AI in cardiology
Narendra Kumar, HeartbeatsZ Academy, United Kingdom
Artificial Intelligence (AI) is transforming cardiovascular medicine by enhancing diagnostic accuracy, treatment selection, and patient outcomes. Machine learning algorithms now analyse complex cardiac imaging with superhuman precision, detecting subtle patterns in echocardiogram [....] » Read More
Title : The development of human relaxin-2 for heart failure with preserved ejection fraction, HFpEF
Thomas Bernd Dschietzig, Relaxera GmbH & Co. KG, Germany
Human relaxin-2 (hRlx-2) is a hormone of pregnancy that has engendered a great deal of interest as a therapy for various cardiovascular and inflammatory diseases, among them Acute Heart Failure and Systemic Scleroderma. Here, we propose and summarize data showing that Rlx-2 repre [....] » Read More
Title : Ex-situ organ perfusion and cardiac performance improvement
Y J H J Taverne, Erasmus University Medical Center, Netherlands
Cardiac transplantation remains the golden standard for patients with end-stage heart failure when therapeutic approaches and interventions fail to reverse HF progression. Traditionally, hearts are transplanted from brain-death (DBD) donors where the heart is beating at time of p [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through biodesign-driven and inspired biotech, translational applications and cardiology-related marketing to secure the human healthcare, wellness and biosafety
Sergey Suchkov, N. D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the recogni [....] » Read More
Title : Use of mitochondrial ROS inhibitor to protect coronary microvascular/endothelial function
Jun Feng, Alpert Medical School of Brown University, United States
Cardioplegic ischemia/reperfusion (I/R), hypoxia/re-oxygenation (H/R) and diabetes mellitus (DM) are associated with increased oxidative stress which contribute to coronary microvascular/endothelial dysfunction. Mitochondrial reactive oxidative species (mROS), a major source of R [....] » Read More
Title : Heart of stone: A rare case of incidentally detected endocardial calcification
Vaibhav Sharma, St. Louis Heart and Vascular, United States
Background: Endocardial calcification is a rare cardiac condition with limited documented cases, particularly in non-tropical regions. This case report explores an unusual presentation of incidental endomyocardial calcification in a patient without typical predisposing systemic d [....] » Read More
Title : Green alert: Myocardial infarction triggered by marijuana use
Vaibhav Sharma, St. Louis Heart and Vascular, United States
Background: The cardiovascular implications of marijuana use have gained increasing attention in recent medical literature. While chronic cannabis consumption has been linked to various cardiovascular events, comprehensive documentation of acute myocardial infarction in young adu [....] » Read More
Title : Myocarditis in desmoplakin cardiomyopathy: A misdiagnosed entity or a distinct phenotype?
Natasha Ghalib, Case Western Reserve University, United States
Background: Desmoplakin (DSP) cardiomyopathy is a distinct form of arrhythmogenic cardiomyopathy (ACM), often presenting with left-dominant or biventricular involvement. A subset of these patients exhibits a myocarditis-like phenotype, characterized by acute chest pain, troponin [....] » Read More
Title : Minimal invasive pediatric and adult congenital cardiac surgery
Y J H J Taverne, Erasmus University Medical Center, Netherlands
Full midline sternotomy remains the most common incision to correct congenital cardiac defects. Although many minimal invasive programs exist for the adult population worldwide, only a few centers have adopted such a program for the pediatric population. The rise of novel interve [....] » Read More
Title : The promising future of the unique translational tool to manage self-renewal of cardiac cells and to support regeneration in the post-infarction period
Sergey Suchkov, N. D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
The approaches securing cardiac regeneration in post-infarction period are not available to be practiced. The key problem is the identity of cells be born to generate functionally active cardiac myocytes replenishing those being lost during ischemia. With identification of reside [....] » Read More
Title : Multiple cerebral infarcts caused by left ventricular thrombus: A multidisciplinary challenge
Sara Ismail Abdelhalim Ismail, Al-Sabah Hospital-Medical, Kuwait
Introduction: Left ventricular (LV) thrombus accounts for up to 10% of cardioembolic strokes. It is frequently observed in patients with a history of myocardial infarction, particularly those with anterior STEMI, reduced left ventricular ejection fraction (LVEF), non-ischemic car [....] » Read More
Title : Cardiac channelopathies – Silent threat to sudden cardiac death
Salla Surya Prakasa Rao, ESIC Medical College and Hospital, India
Sudden Death refers to the death of an individual within 24 hrs after being seen alive and in a normal state of health. The currently identified Channelopathies known to cause syncope and sudden death include Long QT Syndrome (LQTS), Short QT Syndrome (SQTS), Brugada Syndrome (Br [....] » Read More
Title : A rare and fatal complication of dengue fever: Spontaneous coronary artery dissection
Umar Badshah, Saidu Teaching Hospital, Pakistan
Dengue fever, a tropical disease characterized by fever, haemorrhagic manifestations, and organ impairment, can have rare and fatal complications. We report a case of spontaneous coronary artery dissection (SCAD), a rare but potentially fatal complication of Dengue fever. We repo [....] » Read More
Title : Resource utilization and outcomes in surgical turndown patients undergoing either orbital or rotational atherectomy
Hassan Saleh, NewYork-Presbyterian Hospital / Weill Cornell Medical Center, United States
Patients with surgical anatomy turned down for coronary artery bypass surgery often have complex disease and high-risk features. We identified all patients who underwent either orbital (OA) or rotational atherectomy (RA) at our institution between January 2021 and December 2024, [....] » Read More
Title : Seizure-like episode unmasking torsade’s de pointes: A rare presentation of an arrhythmic emergency
Kanchan Kanchan, Birmingham Heartlands Hospital, United Kingdom
We present the case of a 40-year-old male who experienced a seizure-like episode, later diagnosed as torsade's de pointes (TDP), highlighting the diagnostic and management challenges of this atypical presentation. The episode characterized by generalized shaking without tongu [....] » Read More
Title : Correlation of troponin and homocysteine levels with coronary artery disease in patients on hemodialysis - A preliminary study
Sofra Maria, Aretaieion University Hospital, Greece
Background and Aims: The aim of this study is to investigate the association of troponin and homocysteine levels with coronary artery disease and the cardiovascular risk in patients with end stage kidney disease (ESKD). Methods: 50 patients on HD > 6 months (mean duration 3 [....] » Read More
Title : Correlation of homocysteine levels with lipid profile and coronary artery disease in patients with chronic kidney disease under hemodialysis - Preliminary findings
Sofra Maria, Aretaieion University Hospital, Greece
Background and Aims: Patients with end-stage chronic kidney disease (ESRD) exhibit disturbances in protein and amino acid metabolism and elevated homocysteine levels. The latter has been implicated as an independent risk factor for cardiovascular events in these patients. The aim [....] » Read More
Title : Left atrioventricular coupling index as a novel prognostic marker of adverse events in heart transplant patients
Chun Wu, Huazhong University of Science and Technology, China
Purpose: Decreased diastolic(DD) function may be one of the early manifestations of acute rejection after heart transplantation. Left atrioventricular coupling index (LACl) is associated with DD severity. The purpose of this study was to investigate the novel prognostic value of [....] » Read More
Title : Caught in a red and blue squeeze: A plaque-free coronary crisis
Zoya Khan, Lakeland Regional Health, United States
Introduction: Anomalous origin of the right coronary artery (RCA) is a rare congenital condition, accounting for less than 1% of coronary anomalies. While many patients are asymptomatic, the anomalous course can lead to myocardial ischemia through external compression rather than [....] » Read More
Title : Hidradenitis suppurativa in cardiac transplant recipients: Implications of immunosuppression on disease activity and clinical outcomes
Natasha Ghalib, Case Western Reserve University, United States
Background: Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease affecting apocrine gland-bearing regions and characterized by painful nodules, abscesses, and sinus tract formation. Although traditionally considered a dermatologic condition, emerging ev [....] » Read More
Title : Epoprostenol infusion in pulmonary hypertension: A case of mechanical complication and management
Ali Elshamy, Northampton General Hospital, United Kingdom
Introduction: Pulmonary hypertension is a chronic progressive disease characterized by raised pulmonary vascular resistance ultimately leading to right sided heart failure. Amongst the current available options for treatment, Epoprostenol has been widely proven to improve sy [....] » Read More
Title : Changes on sleep quality after treatment of mandibular advance device for sleep apnea: 24-hour holter-based cardiopulmonary coupling analysis
Jin Oh Na, Korea University Guro Hospital, Korea, Republic of
Background: The purpose of this study is to report the treatment effects of mandibular advance device (MAD) on patients with sleep apnea based on cardiopulmonary coupling (CPC) analysis. Method: Patients with mild to moderate obstructive sleep apnea were enrolled in a prospect [....] » Read More
Title : Transient ST-elevation MI diagnosed by holter monitoring
Nabihah Hussaini, University Hospital Lewisham, United Kingdom
Presentation: A 54-year-old woman was referred with an 8-week history of pressure sensations over the chest and epigastrium unrelated to exertion. She presented to the Emergency Department 4 weeks prior but self-discharged against medical advice due to the long wait time. Diag [....] » Read More
Title : Evaluation of echocardiography appropriateness in acute medical unit: A retrospective cohort study
Ahmad Zainal Mazlam, St James's Hospital, Ireland
Background: Echocardiography is a widely used diagnostic tool in Acute Medical Units (AMUs), but its inappropriate use can strain healthcare resources. The Appropriate Use Criteria (AUC) for echocardiography, developed by the American College of Cardiology (ACC) and the American [....] » Read More