Title : Impact of percutaneous coronary intervention on renal function in patients with coronary heart disease
Abstract:
There is a complex relationship between cardiac and renal function. The effect of the percutaneous coronary intervention (PCI) on the renal function in patients with coronary artery disease remains poorly understood. The aim of the present study was to assess renal function change, including the time course of renal function, after elective PCI in patients with improved renal function and identify the predictors of renal function with major adverse cardiovascular events. In this retrospective cohort study, we examined data from 1572 CHD patients who underwent coronary angiography (CAG) or PCI. Patients(n=1240) receiving elective PCI and patients (n=332) receiving CAG between January 2013 and December 2018 were included. Pre-PCI and procedural variables associated with post-PCI eGFR, change in renal function after follow-up post-PCI, and association of post-PCI eGFR on major adverse cardiovascular events were assessed. Follow-up renal function was unchanged or improved in 88.7% of PCI group patients. In an analysis of patients undergoing PCI, the treatment of PCI was found to independently correlate with IRF following coronary angiography (OR 4.561 [95%CI:2.556-8.139];P?0.001). The area under the ROC curve is 0.763(model with the treatment of PCI).Improved renal function (IRF) and stable renal function were significantly associated with lower incidence of major cardiovascular adverse event.
Audience Take Away:
- In patients with CHD undergoing PCI, renal function is more likely to stay the same or improve than worsen
- IRF was relatively common in non-dialysis patients with CHD and advanced renal dysfunction who underwent PCI
- IRF was associated with favorable cardiovascular outcomes
