Title : Advancements in atherothrombotic disease treatment: Unveiling the potential of SGLT2/1 Agents
Robert J Chilton, UT Health San Antonio, United States
Atherothrombotic disease, characterized by the formation of atherosclerotic plaques leading to arterial thrombosis, is a significant cause of morbidity and mortality worldwide. Despite considerable progress in therapeutic interventions, there remains an unmet need for novel treat [....] » Read More
Title : Antiplatelet agents as a novel therapy of heart failure due to myocardial infarction
Naranjan Dhalla, St. Boniface Hospital Albrechtsen Research Centre, Canada
Although different antiplatelet agents are used for the prevention of thrombosis and treatment of ischemic heart disease, very little information regarding therapeutic potential of these agents in heart failure is available. We have investigated the effects of some antiplatelet a [....] » Read More
Title : Advanced molecular and cellular mechanisms for pulmonary hypertension
Yong Xiao Wang, Albany Medical Center, United States
Pulmonary hypertension (PH) is a common and devastating lung disease. The current primary interventions for this disease are to use non-specific vasodilators, but patients do not always respond well to these non-specific vasodilators. Voltage-dependent potassium channels and stor [....] » Read More
Title : Protecting cardiac potassium channels as a novel strategy to prevent ischemia-associated arrhythmias and sudden cardiac death
Shetuan Zhang, Queen’s University, Canada
The human ether-a-go-go–related gene (hERG) encodes the potassium channel Kv11.1 (commonly known as hERG) that conducts the rapidly activating delayed rectifier potassium current (IKr). Normal function of hERG is critical for cardiac repolarization and its dysfunction cause [....] » Read More
Title : System methods to define master regulator of cell identity in development and diseases
Kaifu Chen, Cardiology Department, Boston Children’s Hospital, Boston, MA, USA, United States
A cell type is determined by the network function of its cell identity genes, including master transcription factors that govern the expression status of this network. Cell identity transition is fundamental in normal differentiation and development, whereas a cell that loses its [....] » Read More
Title : Left atrial appendage occlusion during cardiac surgery to prevent stroke: A systematic review and meta-analysis
Alaa A Sayed, UPMC, United States
Introduction: Atrial fibrillation accounts for one-sixth of all strokes, potentially leading to significant disability and death. The left atrial appendage (LAA) is the most common location for thrombus formation that can cause ischemic strokes. Excluding the LAA has been hyp [....] » Read More
Title : Optimal adoption of the CNIC-polypill strategy (acetyl salicylic acid, atorvastatin and ramipril) in routine clinical practice: Global expert consensus and endorsement for enhanced cardiovascular outcomes
Jose Maria Castellano Vazquez, National Center for Cardiovascular Research (CNIC), Spain
Background: The incidence of recurrent cardiovascular (CV) events (CVe) and all-cause mortality is high among patients in secondary prevention. The SECURE trial demonstrated that the CNIC-Polypill Strategy combining acetylsalicylic acid [ASA], atorvastatin and ramipril into a [....] » Read More
Title : Advancing the care of heart failure and T2DM
Osama ElmaraghI, MOH Kuwait, Kuwait
Heart failure is a clinical syndrome caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or elevated intracardiac pressures at rest or during stress.1 Heart failure poses a significant global disease burden, more than 60 million [....] » Read More
Title : Prevalence of erectile dysfunction and its associated factors among Filipino adult patients in a tertiary hospital: A cross-sectional study
Kimberly L Co, Cardinal Santos Medical Center, Philippines
Background: Erectile Dysfunction (ED) is an important worldwide health issue that affects nearly half of men over the age of 40 years. It has a significant negative impact on the quality of life and life satisfaction of the affected individual as well as his partner. The prim [....] » Read More
Title : Effect of sodium glucose co-transporter 2 inhibitors (SGLT2i) on ejection fraction in acute myocardial infarction: A systematic review and meta-analysis
Marc Jason Ng, Cardinal Santos Medical Center, Philippines
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are principally known as agents for the control of Type 2 diabetes mellitus (Type 2 DM). In recent years, they have gained more attention, especially for their role in cardiovascular protection in Type 2 diabetes p [....] » Read More
Title : Rheumatic heart disease in the 21st Century: Challenges and opportunities
Susy Kotit, Aswan Heart Centre, Egypt
During the presentation, the epidemiology and background of Rheumatic Heart Disease (RHD), with attention to statistics, global burden, and consequences will shortly be presented, followed by data on the resurgence of the disease in areas where it was previously eradicated. [....] » Read More
Title : The prevalence, clinical aspect and risk factors of aortic stenosis among hemodialysis patients attending Hawari Nephrology Centre of Benghazi
Malak Mohammed Saed Abdulqdir Alagoury, Libyan International Medical University, Libyan Arab Jamahiriya
Background: Cardiac valve calcifications are common among end stage renal disease (ESRD) patients. Valves most commonly involved are mitral and secondarily aortic valves. In Libya, there is a lack of research in this field. Thus it is our motivation to conduct this study, whi [....] » Read More
Title : One year experience in “umbrella like” myocardial “no touch” surgical closure of the postinfarction posterior ventricular septal rupture
Sasa Kacar, University Clinical Center of Serbia, Serbia
As we already know, the well-established surgical treatment of the postinfarction ventricular septal defect (VSD) has 30-day mortality more than 40%. Last year in Valencia, the “novel” technique invented by Torre M. et all, from Salerno, Italy, was presented. It of [....] » Read More
Title : 3d echocardiographic assessment of post pacemaker right ventricle dysfunction
Dinesh kumar, Gauhati Medical College & Hospital, India
Introduction: Several studies have shown that unfavourable ventricular remodelling, mechanical dyssynchrony, and altered regional perfusion are all caused by the right ventricular (RV) pacing leading over time to development of Left Ventricular dysfunction. Nevertheless, the [....] » Read More
Title : Safety and efficacy of chlorthalidone vs hydrochlorothiazide in hypertension
Jaykaran Charan, All India Institute of Medical Sciences, India
Hypertension is associated with an increased risk of complications and deaths from cardiovascular diseases. Thiazide diuretics, one of the first-line drugs for hypertension, include chlorthalidone and hydrochlorothiazide. This systemic review and meta-analysis aim to analyze the [....] » Read More
Title : TIMI risk index as a predictor of no-reflow phenomenon after Primary PCI in Patients presented with ST Segment Elevation Myocardial Infarction (STEMI)
Mohammed Soliman Abd Elhafeez, Benha University, Egypt
Background/Aim: Coronary artery disease and acute coronary syndrome (ACS) are the major causes of death, worldwide. Risk assessment for patients with ACS is necessary to minimize morbidity and mortality. GRACE risk score (GRS), TIMI risk score (TRS), and the TIMI risk index ( [....] » Read More
Title : A case of amaurosis fugax, infectious or embolic?
Alaa A Sayed, UPMC, United States
The patient is a 54-year-old female with past medical history of Dilation and curettage (D&C) who presented with left sided monocular vision loss 5 months prior to admission. She was evaluated by stroke with comprehensive workup that has been negative. She obtained TTE was si [....] » Read More
Title : The Underrepresented: A rare form of hypertrophic cardiomyopathy
Cynthia Okafor, University of Texas Medical Branch, United States
Hypertrophic cardiomyopathy is a disease of the myocardium with an autosomal dominant inheritance pattern. Its primary cause is a mutation in the cardiac sarcomere proteins with contractile function. A defining feature and major hallmark of the disease is a left ventricular obstr [....] » Read More
Title : Coronary cameral fistula from the left circumflex artery to the left ventricle contributing to heart failure: A case report
Lianne Marie R Ramos, Cardinal Santos Medical Center, Philippines
Coronary cameral fistulae are occasionally incidental findings present in less than 1% of the population and 0.1%-0.2% of coronary angiographic studies. In children, coronary artery fistulae account for around half of coronary vasculature anomalies. Most commonly, these drain fro [....] » Read More
Title : Impact of percutaneous coronary intervention on renal function in patients with coronary heart disease
Bing Ji, Tongji University, China
There is a complex relationship between cardiac and renal function. The effect of the percutaneous coronary intervention (PCI) on the renal function in patients with coronary artery disease remains poorly understood. The aim of the present study was to assess renal function chang [....] » Read More
Title : Treatment of atrio-esophageal fistula following epicardial ablation for atrial fibrillation
David W Yaffee, Hartford HealthCare, United States
Atrio-esophageal fistula is a rare but life-threatening complication of epicardial atrial ablation. Concomitant surgical repair of the heart and esophagus carries a high morbidity and mortality, especially when repair is attempted without cardiopulmonary bypass. We report the pre [....] » Read More
Title : Frequencies of genes polymorphisms associated with warfarin dosage in the Kazakh population
Alexandra Murtazaliyeva, JSC “Scientific Center of Obstetrics, Gynecology and Perinatology”, Kazakhstan
Introduction: Statistics show that about 10,000 open heart surgeries are performed in Kazakhstan, with more than 3,000 patients with acquired heart defects. Warfarin is the primary oral anticoagulant to prevent complications after surgery in Kazakhstan. Most studies [....] » Read More