StreptInCor, a candidate vaccine against S. pyogenes is based on protective 55 amino acids residues of C-terminal portion of the M protein. Experimental assays have demonstrated that the StreptInCor peptide induces high titers of opsonic and neutralizing and protective anti [....] » Read More
We conducted a comparative analysis of ADMA plasma concentration in two groups of patients diagnosed with arterial hypertension (AH). Group I - patients with uncontrolled course of disease and group II- patients with controlled course of hypertension. We studied the correlation a [....] » Read More
Introduced 30 years ago, reperfusion therapies have become standard of care in the acute management of ST elevation MI. The criteria for assessing success of these strategies have not kept apace with the refinement of primary PCI systems of care. It is about time these legacy mea [....] » Read More
Background: It is well known that diabetic patients have increased oxidative stress with different degrees of endothelial dysfunction. Although studies have demonstrated the benefit of the use of high dose of Allopurinol in improving the endothelium function, its impact on diabet [....] » Read More
Background: Discharging patients with acute myocardial infarction or unstable angina from the emergency department (ED) because of missed diagnoses can have dire consequences. In 2015, ESC guideline recommends the 0-hour/ 1-hour troponin measurement algorithm (the 0-1 algorithm) [....] » Read More
Aim: Assessment of the clinical condition, quality and prognosis of life in a cohort of CAD patients in comorbidity with other chronic-non-communicable diseases (COPD and type 2 diabetes). Materials and methods: A cohort study included 220 patients of both sexes aged 39 to 69 [....] » Read More
Background: Vascular dementia and Alzheimer’s disease (AD) share an association with hemodynamic risk factors. Exercise can improve cerebral blood flow (CBF), which is associated with a decrease in cognitive decline. However, patients with AD or mild cognitive impairment (M [....] » Read More
Background: Cardiac rehabilitation (CR) has been shown benefits in improving patients’ outcomes. However, the nonadherence to the prescribed physical activity and elected level of risk factors remain the concerns for patients after CR. Objective: To evaluate the effect of a [....] » Read More
Transradial percutaneous coronary intervention (TRPCI) is rapidly becoming the gold standard especially in primary percutaneous coronary intervention (PCI). Results of the ARCUS trial (Effects of trAnsRadial perCUtaneouS Coronary Intervention on Upper Extremity Function) showed u [....] » Read More
Blood flow acceleration increases from the left ventricular outflow tract, to the sinotubular junction and the ascending aorta, while it must be decreasing due to the flow turbulences in the Valsalvae sinuses. Energy of the pulse wave in the arterioles is up to 7.2 times higher, [....] » Read More
Cardiac pacemakers and arrhythmia devices are standard therapies in patients. International guidelines recommend how to handle patients equipped with cardiac devices during anesthesia. However, these guidelines are not really helpful in emergency cases, since there is not enough [....] » Read More
Objectives: The report focuses the associations of mean arterial pressure (MAP) for shock patients based on probabilistic modeling with a real data set of 113 shock patients. Background: The relationship of MAP with the other cardiac and biological factors is v [....] » Read More
Implantation of a PFO-occluding device may reduce the risk of recurrent stroke or transient ischemic attack compared with medical therapy in patients with cryptogenic stroke. However, there is a debate about the indication for closure and the power of secondary prevention by [....] » Read More
Takayasu arteritis (TA) is a rare chronic vasculitis affecting the aorta and its main branches causing segmental and granulomatous inflammation. The underlying inflammatory process associated with the disease is believed to be an important risk factor in in atherogenesis causing [....] » Read More
Background: This case control study attempted to determine the relationship between irregular intake of antihypertensive drugs and stroke among hypertensive patients. Demographic profile of the patients was analyzed thoroughly, and risk factors among those characteristics were al [....] » Read More
Acute coronary syndrome (ACS) is one of the leading causes of increased morbidity and mortality worldwide. Although ACS-related mortality has been profoundly linked with the serum potassium level on admission, recent results seem to contradict the established guidelines. Aims.&n [....] » Read More
Reperfusion injury attenuates the beneficial effects of reperfusion therapy for ST-segment elevation myocardial infarction (STEMI). No approach has proven successful in preventing this injury in the clinical setting, thus far. We recently reported a new approach, postconditioning [....] » Read More
Background: Post-menopausal women have increased risk of developing cardiovascular disease, especially for those who are overweight or obese. Healthy diet and increasing physical activity can improve cardiovascular health among postmenopausal women, whereas most of intervention s [....] » Read More
According to recent guidelines, Syntax score up to 22 PCI is preferable over CABG while for syntax score >22 CABG is preferred. Syntax score should not be the sole criterion of appropriateness of PCI success. Other clinical features like age, renal function, ejection [....] » Read More
Objective: To develop a patient specific induced pluripotent stem cells (iPSCs) disease model of Loeys-Dietz syndrome (LDS) and to identify how TGFBR mutation result in dysfunction of vascular smooth muscle cell (VSMC) and implicated in LDS vascular pathogenic course. Metho [....] » Read More
Objectives: The aims of this study were to assess the accuracy of multiple echo parameters of diastolic dynamics and the 2016 ASE/EACVI algorithm to detect elevated invasive LV diastolic pressures in patients with normal ejection fraction; the accuracy of the 2016 algorithm was c [....] » Read More
Acute limb ischemia (ALI) is a sudden decrease in limb perfusion that may threaten limb viability. The most common cause is acute arterial total or near-total occlusion. Mortality and morbidity rate were high even after surgical or endovascular intervention. Early recognition and [....] » Read More
Atrial flutter is a form of arrhythymia resulted from rapid spontaneously formed electrical circuit in the atrium. Atrial flutter can be caused by scarring of the heart resulting from prior cardiac disease or heart surgery, but it can also occur in some patients with no other ide [....] » Read More
Of 12 moon walkers, James Irwin on day after return from Apollo 15 mission, showed extraordinary bicycle ( B) stress test (ST) hypertension ( 275/125) after 3 minutes exercise; supervising > 5000 maximum treadmill ST, author never witnessed ST- blood pressure appro [....] » Read More
Title : Oral pathogens, CVD and home oral care: Critical links in the prevention of heart disease
James L Ratcliff, Rowpar Pharmaceuticals, United States
Oral microbes are directly involved in the pathogenesis of cardiovascular diseases. Periodontal pathogens, such as Porphyromonas gingivalis, are found diseased cardiovascular lesions. Also, pathogens associated with dental caries, such as Streptococcus mutans, have been det [....] » Read More
Title : Coronary artery spasm: Pathogenesis, diagnosis and treatment
John Horowitz , University of Adelaide, Australia
Coronary artery spasm (CAS) may involve predominantly large or small coronary arteries, and usually presents as episodes of prolonged ischaemic-type chest pain occurring randomly, but with a tendency toward cyclic periodicity. Diagnosis is currently difficult clinically, and many [....] » Read More
Title : Biomarkers guided therapy for risk stratification and prognostication of patients treated for acute coronary syndrome
Marija Vavlukis, Saints Cyril and Methodius University of Skopje, Macedonia, The Former Yugoslav Republic of
There are cumulating evidences of prognostic implications of cardiac biomarkers in patients with acute coronary syndrome (ACS). The prognostic role of troponin (hsTn), natriuretic peptides (NPs), stress glycaemia, HbA1c, are described in different extent in the current trials. Th [....] » Read More
Title : TGF-B signaling in smooth muscle differentiation and vascular remodeling
Shiyou Chen , University of Georgia, United States
Vascular smooth muscle (SM) plays a fundamental role in embryonic development and in adult life, whereas abnormal SM differentiation or phenotypic modulation is associated with congenital heart diseases, atherosclerosis, restenosis following angioplasty, post-transplant vasculopa [....] » Read More
Title : Recanalization of the Superior Vena Cava and its tributaries in patients requiring Chronic Venous Access or Pacemaker insertion, techniques, tips, and safety
Stephen Kee, UCLA Health, United States
geles, CA 90095 This presentation will deal with patients whose supradiaphragmatic veins have been compromised, usually because of prior prolonged venous access, or other interventions (pacemaker wires). Many of these patients have need for continued catheterization, or placement [....] » Read More
Title : Ulnar access coronary artery intervention: Current scenerio
RK Gokhroo, JLN Medical college, India
Ulnar access is a simple feasible and easy alternate access to radial access for coronary angiography and interventional procedure. The technique is difficult for the learners so discussion about technique and feasibility of all interventional procedure through route is feasible. [....] » Read More
Title : Assessment of right ventricular systolic function by two dimensional echocardiography and longitudinal strain: Is right ventricular systolic function influenced by right atrial function?
Veena Raizada, University of New Mexico Health Science Center, United States
Right ventricular (RV) systolic function is impaired in several cardiopulmonary diseases, including heart failure of varied etiologies, valvular diseases, cardiomyopathies, pulmonary hypertension, acute pulmonary embolism, collagen vascular diseases and pericardial diseases. Exam [....] » Read More
Title : Oral anticoagulation during pregnancy: Current scenerio
Kamla Gokhroo, Geetanjali Institute of Medical sciences, India
Audience Oral anticoagulation drug usage is a challenging field during pregnancy. Many newer oral anticoagulation agents have come in the basket of therapeutic armamentarium like NOACs.their knowledge is of utmost importance for the treating physicians and obstetricians. Audience [....] » Read More
Title : New aspects of regulation of cardiac action potential duration
Peter P Nanasi, University of Debrecen, Hungary
I n this talk three basic features of regulation of action potential duration (APD) are discussed, each based on changes in the net membrane current (Inet) during the plateau of the AP. 1. The reverse rate-dependent nature of drug effects on APD means that any drug-induced change [....] » Read More
Title : ECMO past, present and future
Cyril Jacob Chacko, Royal Wolverhampton NHS Trust, United Kingdom
The use of mechanical circulatory support has been increasing over the last 2 decades. The indications of extracorporeal life support (ECLS) are respiratory failure refractory to conventional management, post MI cardiogenic shock, post cardiotomy cardiogenic shock, ECMO CPR, PE, [....] » Read More
Title : The role of mechanical circulatory support in advanced heart failure
Zumrut Tuba Demirozu, University Hospital Istanbul, Turkey
Heart Failure (HF), is a well- recognized costly public health problem with high patient mortality.According to Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs) Reports increasing number of Ventricul Assist Device (VAD) implantations and classified s [....] » Read More
Title : Electrocardiogram of the neonate and infant
Konrad Brockmeier, University of Cologne, Germany
The ECG in children has a number of characteristic differences compared to the ECG of the adult. The transition of the ECG in neonates after birth represents dynamic changes of the circulatory system due to the postnatal adaptation, different physiologic properties of the fetal a [....] » Read More
Title : Next-Generation Sequencing in clinical diagnostics: Genetic testing, variant classification, and functional analysis
Rick Kamps, Maastricht University, Netherlands Antilles
Next-generation sequencing (NGS) technology expanded in the last decades with significant improvements in the reliability, sequencing chemistry, pipeline analyses, data interpretation and costs. Such advances make the use of NGS feasible in clinical practice nowadays. This presen [....] » Read More
Title : A novel biomarker for cardiovascular conditions
Jian Guan, University of Auckland, New Zealand
Consistent evidence links insulin-like growth factor (IGF)-1 deficiency to a range of cardiovascular and metabolic disorders including hypertension and stroke. A biomarker for IGF-1 function would be clinical useful for the prognosis of cardiovascular conditions. While plasma IGF [....] » Read More
Title : Unusual intracardiac mass beyond common sense
Lianyi Wang, First Hospital of Tsinghua University, China
I ntracardiac mass is relatively rare compared to in other organs. The nature of the mass directly determines the treatment plan and prognosis of patients. Generally speaking, it is not difficult for doctors to differentiate between tumour mass and intracardiac thrombus. Atrial t [....] » Read More
Title : Pharmaco invasive strategy for STEMI reperfusion in North African countries
Walid Jomaa, Fattouma Bourguiba University Hospital, Tunisia
Primary percutaneous coronary intervention (pPCI) is the current gold standard in ST-elevation myocardial infarction (STEMI) management. Pharmacoinvasive strategy (PS) in STEMI consists in the use in a timely manner of pharmacological fibrinolysis for STEMI when pPCI is not immed [....] » Read More
Title : Effect of endurance training conducted under hypoxia conditions, on change of exercise tolerance of patients after myocardial heart infarction (STEMI) - a pilot study
Tomasz Gabrys, University of West Bohemia in Plzen, Czech Republic
It is very important to monitore closely and takes appropriate precautions patients after myocardial infarction because every year many of them go High Mountain trekking or practice winter sports. Material and methods: In 22 training units under artificial, normobaric hypoxia con [....] » Read More
Title : Relationship of glycemic status, arterial hypertension and macrovascular complications: Results of a multicenter cohort study
Mekhman N Mamedov, National Research Center for Preventive Medicine, Russian Federation
Aim: To study the relationship between glycemic controls, arterial hypertension (AH) and macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Methods: 528 patients with T2DM, aged 30–69 years (30.5% men, 69.5% women) were included in the clinical an [....] » Read More
Title : A low-cost, automatic, external defibrillator and pacemaker for home/office to prevent sudden cardiac death
A Teddy Weiss, Hadassah University Hospital, Israel
S udden cardiac death(SCD)-caused by ventricular fibrillation(VF) or standstill- occurs in about 1000 persons/day in US alone. Since survival drops by 10% for every minute delay- no ambulance in the world will be quick enough to save them. The existing AEDs, that are [....] » Read More