Dr. Koyama has expertise in research in myocardial reperfusion injury. He has recently developed a new treatment strategy for myocardial reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI), based on the results of his previous experimental study using guinea-pig myocytes that was published in Am J Physiol in 1991. He is basically a clinical cardiologist, performing percutaneous coronary intervention himself. But his experiences not only in STEMI treatment but also in animal experiments inspired him to develop a new treatment strategy for myocardial reperfusion injury, i.e. postconditioning with lactate-enriched blood.