HYBRID EVENT: You can participate in person at Madrid, Spain or Virtually from your home or work.

5th Edition of Cardiology World Conference

September 5-7, 2024 | Madrid, Spain

September 05 -07, 2024 | Madrid, Spain
CWC 2019

James L Ratcliff

James L Ratcliff, Speaker at Heart Conferences
Rowpar Pharmaceuticals, United States
Title : Oral pathogens, CVD and home oral care: Critical links in the prevention of heart disease


Oral microbes are directly involved in the pathogenesis of cardiovascular diseases. Periodontal pathogens, such as Porphyromonas gingivalis, are found diseased cardiovascular lesions.  Also, pathogens associated with dental caries, such as Streptococcus mutans, have been detected in plaque found on heart value and arterial wall.  With the exception of periodontal and cariogenic bacteria, the polymicrobial makeup of arterial plaque is distinct, suggesting both may be contributors to CVD.  This session examines the relationship between oral bacteria and cardiovascular disease and what steps can be taken to minimize their impact with particular emphasis on its implications for the design of home oral care. Periodontal and cariogenic bacteria are endogenic, carried by individuals from birth.  The oral biofilms in which they thrive protect them from many home oral care products and regimes, and the biofilms regenerate within 2-3 days of a professional dental exam and cleaning.  Within the oxygen-scarce environment of biofilms, periodontal and cariogenic pathogens tend to overgrow, causing inflammatory insult to host, penetration through oral lesions to the blood stream, and dissipation throughout the body. Therefore, the nature and capacity of home oral care to mitigate the overgrowth of oral pathogens associated with CVD becomes critical to ongoing oral and heart health.  The relationship between oral health and CVD is reviewed from the perspective of preventative care given the challenges posed by the oral microbiome and the oral pathogens resident within.


James L. Ratcliff is Chairman of the Board and CEO of Rowpar Pharmaceuticals, Inc., Scottsdale, AZ, maker of the Cl?SYS brands of oral care products. In 2017 and 2018, Rowpar was cited by Corporate Livewire as innovative leader in oral care for North America. In 2014, Rowpar received the U.S. Small Business Administration’s Exporter of the Year Award.  From 1989 to 2000, Dr. Ratcliff served as senior research scientist, professor and director, Center for the Study of Higher Education at the Pennsylvania State University.  From 1979 to 1989, Dr. Ratcliff was professor and program head for higher education at Iowa State University.  Dr. Ratcliff is author of 120 articles, books, book chapters, is co-inventor on over 40 patents and patents pending.  He is active member of the Arizona Biotechnology Assn., American Academy of Oral and Systemic Health, American Education Research Assn., and the International Association for Dental Research. He holds a Ph.D. in Higher Education from Washington State University, a M.A. in History from Washington State University, and a B.A. from Utah State University.