Aim: To study the relationship between glycemic controls, arterial hypertension (AH) and macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Methods: 528 patients with T2DM, aged 30–69 years (30.5% men, 69.5% women) were included in the clinical and epidemiological study. Values of glycohemoglobin ≥7% were regarded as diabetic decompensation. All patients were conducted a survey, clinical examination, measurement of atropometric and hemodynamic parameters, ECG at rest and ECHO CG. In addition, we determined the carotid intima-media thickness (IMT), the ankle-brachial index, as well as the form and extent of blood flow disorders in the vessels segments of the lower extremities. Cardiovascular diseases are verified by survey, clinical examination and medical records. Results: With inadequate control of diabetes, AH was more common (83.5%), and the severity of AH was significantly more significant (p = 0.023), ECG and EchoCG showed signs of left ventricular hypertrophy. A prolonged antihypertensive therapy was taken by a small proportion of patients, in most cases in the form of a course of treatment and during a rise in BP. In this group of patients, more angina was detected (according to a survey - 7%), ECG signs of CAD (26.7%), EchoCG signs of aortic atherosclerosis (46.7%), myocardial infarction (6.1%) and its ECG signs (37 , 1%), as well as hypokinesis (33.3%) and akinesis (21.0%). Poor glycemic control was associated with frequent occurrence of rhythm disturbances (22.2%), CHF (40.0%), diastolic (54.9%) and systolic dysfunction (20.6%). Stroke (5.2%), severe degrees of stenosis of the carotid arteries increased with decompensation of diabetes, an increase in the IMT was also noted. In the lower limbs, the main type of blood circulation was determined, severe stenosis increased at the periphery, impaired blood flow was noted mainly in the subcompensation stage, and in the popliteal ankle segment also in the decompensation stage. Conclusion: In cases of the inadequate glycemic control in patients with T2DM, macrovascular complications and hypertension were recorded more frequently. This circumstance indicates increased glycemic control and prevention of CVD
Professor Mehman Mamedov graduated from the Moscow Medical Academy named after I.M. Sechenov in 1993. He continued his medical residency at the Central Clinical Hospital of the Presidential Administration of the Russian Federation.
In 1997 Dr. Mamedov received his PhD degree in the National Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation for research titled "Metabolic syndrome components in patients with arterial hypertension". In 2001 he wrote his doctoral thesis on "Clinical and biochemical features of metabolic syndrome and its pharmacological management". He has been working in the National Medical Research Center for Therapy and Preventive Medicine for 26 years, beginning as a researcher and eventually becoming the head of the scientific laboratory.
He is the author of 400 scientific works, 16 monographies in Russian, 4 monographies in English and 3 patents. Hirsch Index: RSCI — 36, Scopus — 6, Web of Science — 6.
Under Dr. Mamedov’s supervision, 10 PhD and 1 doctoral thesis have been defended. Recently, Professor Mamedov M.N. has initiated 12 research projects, including some presented at the congresses of the American College of Cardiology, the European Society of Cardiology, the World Heart Federation, as well as at other international and national scientific events.
Professor Mamedov M.N. annually gives lectures in Russia and other countries. His research interests include: cardiometabolic disorders, lipid metabolism disorders, male health issues, cardiovascular risk assessment and correction, early markers of atherosclerosis, prediabetes and diabetes mellitus, risk factors and cardiovascular disease epidemiology, cardio-oncology, and comorbidities in internal medicine.
Dr. Mamedov is the editor-in-chef of the "International heart and vascular disease journal", member of the editorial board of the "Cardiology" and "Cardiovascular Prevention and
Therapy" journals, head of the Department of Secondary Prevention of Chronic Noncommunicable Diseases of the National Medical Research Center for Therapy and Preventive Medicine, and President of the Cardioprogress Foundation.
Professor Mamedov M. was an executive secretary of the Russian National Congress of Cardiology for 6 years, organizing regional and national scientific conferences. He is one of the founders of the International Forum of Cardiology and Internal Medicine, which has been held annually at the Russian Academy of Sciences since 2012. He has letters of appreciation from the head of the Republic of Ingushetia, ministers of health of the Russian Federation, Uzbekistan, Tajikistan, Belarus, the Chechen Republic and the presidents of the Turkish Society of Cardiology, the Association of Internists of Kazakhstan and the National Health League. In 2019, he was awarded with V.D. Shervinsky medal by the President of the Russian Scientific Medical Society of Internal Medicine for his contribution to the development of medical science.