HYBRID EVENT: You can participate in person at Madrid, Spain or Virtually from your home or work.

5th Edition of Cardiology World Conference

September 5-7, 2024 | Madrid, Spain

September 05 -07, 2024 | Madrid, Spain
Cardio 2024

Emerson Jose De Souza

Emerson Jose De Souza, Speaker at Cardiovascular Conference
VanLab Innovations, Canada
Title : Cardiac myocytes dynamic contractile behavior differs depending on heart segment


Cardiac myocytes originating from different parts of the heart exhibit varying morphology and ultrastructure. However, the difference in their dynamic behavior is unclear. We examined the contraction of cardiac myocytes originating from the apex, ventricle, and atrium, and found that their dynamic behavior, such as amplitude and frequency of contraction, differs depending on the heart segment of origin. Using video microscopy and highprecision image correlation, we found that: (1) apex myocytes exhibited the highest contraction rate (_17 beats/min); (2) ventricular myocytes exhibited the highest contraction amplitude (_5.2 micron); and (3) as myocyte contraction synchronized, their frequency did not change significantly, but the amplitude of contraction increased in apex and ventricular myocytes. In addition, as myocyte cultures mature they formed contractile filaments, further emphasizing the difference in myocyte dynamics is persistent. These results suggest thatthe dynamic behavior (in addition to static properties) of myocytes is dependent on their segment of origin.