A cell type is determined by the network function of its cell identity genes, including master transcription factors that govern the expression status of this network. Cell identity transition is fundamental in normal differentiation and development, whereas a cell that loses its [....] » Read More
The human ether-a-go-go–related gene (hERG) encodes the potassium channel Kv11.1 (commonly known as hERG) that conducts the rapidly activating delayed rectifier potassium current (IKr). Normal function of hERG is critical for cardiac repolarization and its dysfunction cause [....] » Read More
Cardio-HART™ represents a revolutionary advancement in cardiac diagnostics, offering an AI-enabled point-of-care system capable of swiftly diagnosing prevalent cardiac conditions such as heart failure (HF) and valvular heart diseases (VHD) on the very day a patient presents [....] » Read More
Coronary artery abnormalities whether congenital or acquired are an important cause of morbidity and mortality in Children. The current talk will focus on Congenital coronary abnormalities as well acquired coronary disease i.e., Kawasaki disease in children. Coronary Artery An [....] » Read More
Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting millions worldwide. While catheter ablation is a well-established treatment for AF, it carries risks of complications such as pulmonary vein stenosis (PVS) and esophageal injury. Pulse field ablation (PF [....] » Read More
The symptoms shown by frail patients with heart failure (HF) are sometimes different and the most common symptoms may be absent, delaying the diagnosis and finding patients with more severe HF. The use of lung ultrasound in these patients could help to objectify real congestion. [....] » Read More
Background: Preventing high blood pressure and its complications requires identifying its risk factors. This study aims to assess predictors of hypertension and its associated complications among Emirati adults in Abu Dhabi, the United Arab Emirates (UAE). Methods: T [....] » Read More
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are principally known as agents for the control of Type 2 diabetes mellitus (Type 2 DM). In recent years, they have gained more attention, especially for their role in cardiovascular protection in Type 2 diabetes patie [....] » Read More
Background: Erectile Dysfunction (ED) is an important worldwide health issue that affects nearly half of men over the age of 40 years. It has a significant negative impact on the quality of life and life satisfaction of the affected individual as well as his partner. The primary [....] » Read More
Introduction: In the realm of percutaneous coronary intervention (PCI), the management of coronary artery calcium poses a significant challenge, particularly in cases of severe calcification and high-risk patients. Inadequate addressal leads to suboptimal outcomes in terms of ste [....] » Read More
Introduction: Several studies have shown that unfavourable ventricular remodelling, mechanical dyssynchrony, and altered regional perfusion are all caused by the right ventricular (RV) pacing leading over time to development of Left Ventricular dysfunction. Nevertheless, the impa [....] » Read More
Introduction: STEMI mimickers have been described in literature for many decades, but each clinical interaction teaches us new ways to tackle these medical emergencies. This case underscores the need to individualize every case in an effort to avoid delaying life-saving treatment [....] » Read More
Heart failure is a clinical syndrome caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or elevated intracardiac pressures at rest or during stress.1 Heart failure poses a significant global disease burden, more than 60 million [....] » Read More
Objective: To explore the impact of BMI on the short-term mortality and morbidity of patients undergoing CABG. Methodology: Observational study on retrospective data of CABG patients at a tertiary care hospital from 1-7-2017 to 31-12- 2022. Ethical approval was granted and inc [....] » Read More
Background: The aorta can be involved in different pathologies, including congenital, syndromic, and acquired disorders, which may need intervention in any form to prevent disasters. The purpose of this study was to review the types of aortic pathologies treated surgically and th [....] » Read More
Background/Aim: Coronary artery disease and acute coronary syndrome (ACS) are the major causes of death, worldwide. Risk assessment for patients with ACS is necessary to minimize morbidity and mortality. GRACE risk score (GRS), TIMI risk score (TRS), and the TIMI risk index (TRI) [....] » Read More
Background: Individuals with cardiac disease (CD) who are self-employed may experience ability limitation and face especially intensive challenges and uncertainties. These challenges may cause demoralization symptoms and impaired well-being among self-employed people with CD, esp [....] » Read More
Background: Blood pressure (BP) follows an internal 24-hour biological clock (circadian rhythm of BP (CRBP)) which disruption is associated with a worse cardiovascular prognosis. Hence the usefulness of studying the determinants of this CRBP loss at Mbour Hospital, Senegal. [....] » Read More
Background: Left Main Stem (LMS) supplies blood to a great portion of the heart (about 80%) and disease in LMS is serious, often life-threatening. Coronary Artery Bypass Grafting (CABG) is a well-established treatment for LMS disease. The primary objective of this study was [....] » Read More
Introduction: Coronary artery bypass grafting (CABG) is a crucial surgical intervention for severe coronary artery disease. Hypertension, a prevalent comorbidity, may impact post-operative outcomes. This study investigates the effect of hypertension on outcomes in CABG patients. [....] » Read More
Atrial fibrillation (AF) is the most common significant cardiac rhythm disorder and is also a powerful common risk factor for stroke: about 15% of all strokes in the U.S. are attributable to AF. The use of combined antiplatelet and anticoagulant therapy in patients with AF has re [....] » Read More
Takotsubo cardiomyopathy, also known as Broken-heart syndrome, is a non-ischemic cardiomyopathy predominantly affecting postmenopausal women. It is characterized by transient apical ballooning of the left ventricle, resembling the shape of an octopus trap, or "takotsubo" [....] » Read More
Background: With increasing numbers of heart failure patients, there was a serious need for creating a simplified analytical tool to predict outcomes in advanced heart failure. Current tools are complex or old and depend on complex calculations. We prospectively analysed data fro [....] » Read More
PFO is one of the most common congenital heart diseases and fluoroscopic percutaneous closure devices based on non-degradable alloys have been widely used in clinical application and saved numerous patients but some developed countries using biodegradable closure devices un [....] » Read More
This presentation will discuss a retrospective analysis of the impact of administering the PCSK9 inhibitor evolocumab (140 mg/ml, subcutaneously twice a month) in addition to standard therapy (statins + ezetimibe) on LDL cholesterol levels and major adverse cardiovascular events [....] » Read More
Introduction: ASD has a generally good prognosis and if left untreated can lead to PH. The present study was conducted to determine the predictors of treatment success among adult ASD with PH and develop a scoring system based on the identified factors. Methods: Adult patient [....] » Read More
LVAD Therapy has become a safe and successful long-term therapy for patients with advanced heart failure. Off the shelf 24/7 availability allows to treat patients, when necessary, in time. Significant reduction of anticoagulation therapy in recent years has allowed to reduce blee [....] » Read More
Aim: The aim of the study is to analyze the risk of cardiovascular complications (CVC) in an unorganized population of men and women of working age in the Vladimir region. Material and methods: The cross-sectional population-based study included 1,350 men and women aged 3 [....] » Read More
Atherothrombotic disease, characterized by the formation of atherosclerotic plaques leading to arterial thrombosis, is a significant cause of morbidity and mortality worldwide. Despite considerable progress in therapeutic interventions, there remains an unmet need for novel treat [....] » Read More
Objective: To assess the association between maternal congenital heart disease (CHD) and adverse neonatal outcomes, focusing on birth weight, gestational age, Apgar scores, and neonatal intensive care unit (NICU) admissions. Study Design: A retrospective cohort study span [....] » Read More
Motivation of the Work: Identification of barriers in enrolling patients, identification of risk factors, compliance and adherence to treatment and lifestyle changes proposed by specialists Compliance, the patient's behavioral response to the lifestyle change and the prescrib [....] » Read More
Background: Heart Failure (HF) is a prevalent cardiovascular condition associated with a high risk of morbidity and mortality. Anemia is a common comorbidity in HF patients and is often associated with worse outcomes. Intravenous Ferric Carboxymaltose (IV-FCM) has emerged as a th [....] » Read More
Non-communicable diseases, especially cardiovascular diseases (CVD), present a global health challenge, with a disproportionate impact on low and middle-income countries. The majority of global deaths, amounting to 71%, are attributed to non-communicable diseases, with 78% occurr [....] » Read More
Cardiac myocytes originating from different parts of the heart exhibit varying morphology and ultrastructure. However, the difference in their dynamic behavior is unclear. We examined the contraction of cardiac myocytes originating from the apex, ventricle, and atrium, and found [....] » Read More
Human relaxin-2 (hRlx-2) is a hormone of pregnancy that has engendered a great deal of interest as a therapy for various cardiovascular and inflammatory diseases, among them Acute Heart Failure and Systemic Scleroderma. Here, we propose and summarize data showing that Rlx-2 repre [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Introduction: Many studies have demonstrated that biventricular pacing in patients with advanced chronic heart failure significantly improves ventricular hemodynamic, exercise capacity, and reduces mortality and hospitalization rates. Biventricular pacing less than 90% is co [....] » Read More
Purpose: Intradialytic hypertension affects 5–15% of hemodialysis patients, yet relevant studies are relatively scarce. It is also associated with higher interdialytic blood pressure. Beta-blockers can be preferred as antihypertensive drugs due to their superior blood pr [....] » Read More
During the presentation, the epidemiology and background of Rheumatic Heart Disease (RHD), with attention to statistics, global burden, and consequences will shortly be presented, followed by data on the resurgence of the disease in areas where it was previously eradicated. [....] » Read More
Rationale: Mesocardia is the heart in the middle compartment of the chest. The human heart is normally located within the thoracic cavity, medially between the lungs in the mediastinum. Marfan syndrome is an autosomal dominant disorder and multi-systemic genetic disorder that [....] » Read More
Background: Serum uric acid (sUA) has been known to be associated with an increased risk of developing cardiovascular disease in different populations. However, whether this is also the case with Nigerian patients remains understudied. The study aimed to assess the associatio [....] » Read More
Background: In the realm of cardiovascular interventions, the comparison between Drug-Coated Balloon (DCB) and Drug-Coated Stent (DES) revolves around optimizing outcomes in coronary and peripheral artery diseases. While DCBs offer drug delivery without a permanent scaffold, DES [....] » Read More
Background: Hypertrophic cardiomyopathy (HCM) is a general genetic cardiovascular disorder characterized by the thickening of the myocardial wall, which can lead to heart failure and sudden cardiac death. While the genetic basis of HCM has been extensively studied in Western popu [....] » Read More
Background: Percutaneous coronary intervention (PCI) is a common therapeutic procedure for managing coronary artery disease (CAD). Dual antiplatelet therapy (DAPT) involving aspirin and a P2Y12 inhibitor is the standard of care post-PCI to prevent thrombotic events. However, prol [....] » Read More
Introduction: An understanding of the association between apolipoprotein B (Apo-B) and CRP (C-reactive protein) in the development of residual cardiovascular risk is very important when comparing it with atherogenic lipoproteins such as HDL-cholesterol, LDL-cholesterol. Apol [....] » Read More
Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) causes coronavirus disease (COVID-19), a potentially fatal disease that is of immense global public health concern. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) share their ta [....] » Read More
Background: Univentricular heart (UH) is a rare congenital heart malformation, characterized by the absence of two well-developed ventricles and the presence of a single functional ventricle. In these cases, cardiac magnetic resonance imaging or catheterization can be used for pr [....] » Read More
The potential applications of generative AI in the field of cardiology are remarkably broad. Recent research suggests that generative AI is expected to bring a wide range of innovations across the diagnosis and management of cardiovascular diseases. Particularly, the use of gener [....] » Read More
In recent years, wearables are exploding in popularity as unobtrusive devices able to extend traditional healthcare delivery systems. Smart textiles are one of the main innovative types of wearables used for non invasive and continuous monitoring of cardiac activity. A prominent [....] » Read More
Smoking is considered a chronic disease caused by chemical dependence of nicotine. This is highly addicting, it in the brain system it influences our emotions, increases the feeling of pleasure/humor and reduces the anxiety. In a planet with about 8 billion people, around 1, [....] » Read More
Background: Approximately 20.1 million adults in the United States are affected by coronary artery disease. Every year over 4 million coronary angiograms are being performed in Europe and the USA. Over 1700 cardiac catheterization laboratories were present across the United [....] » Read More
Background: Cardiac resynchronization therapy (CRT) is indicated in refractory heart failure patients, with reduced left ventricule ejection fraction (LVEF) and wide QRS, despite optimal medical treatment. The aim of this trial, was to describe baseline characteristics of our stu [....] » Read More
Background: Hypercholesterolaemia and poor blood glucose control are well known risk factors for developing myocardial infarction (MI). Preventative measures have been incorporated into several guidelines around the world. We aim to review our performance in adhering to the [....] » Read More
Introduction: Lyme carditis has been reported in 1 to 5% of diagnosed patients with Lyme disease. The most common presentation of Lyme carditis is conduction system disturbances such as atrioventricular (AV) block. Case Summary: We report the case of a 35-year-o [....] » Read More
The gut-heart axis, a bidirectional communication network between the gut microbiota and the cardiovascular system, has emerged as a critical player in the pathogenesis and treatment of cardiovascular disease (CVD). This comprehensive review aims to elucidate the complex interpla [....] » Read More
Purpose of the study: To study the features of cardiac remodeling depending on the degree of kidney dysfunction. Left ventricular ejection fraction (LVEF) in CHF with kidney dysfunction (KD). Materials and methods of research: A comprehensive examination [....] » Read More
Today, biocompatibility materials are used in the manufacture of various compounds such as metals, polymers, ceramics, and composites. Biomedical polymers are widely used in various synthetic medical devices such as membranes, CPB circuits, ECMO, and dialysis membranes, foams and [....] » Read More
Objective: This study aims to provide an overview of recent research advancements in personalized care for tracheostomy patients and explore how personalized care can enhance the quality of life for patients with long-term tracheostomy. Methods and Materials: Through lit [....] » Read More
Background: The New York Heart Association (NYHA) classification system is a subjective assessment tool used by physicians to evaluate the functional status of patients. In the era of novel pharmacologic treatments for hypertrophic obstructive cardiomyopathy (HOCM), it is c [....] » Read More
Background: Cardiovascular diseases are the world’s number one cause of death. Various scoring systems and indicators, biochemical and otherwise, have arisen to help estimate the cardiovascular risk of populations, thus helping with screening and implementing measures to at [....] » Read More
Objective: To investigate the changes of serum lipoprotein-associated phospholipase A2 (Lp-PLA2), Soluble suppression of tumorigenicity 2 (sST2) and microcirculatory resistance reserve index (MRR) in patients with ST segment elevation myocardial infarction (STEMI) after percutane [....] » Read More
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Title : Antiplatelet agents as a novel therapy of heart failure due to myocardial infarction
Naranjan S Dhalla, St. Boniface Hospital Albrechtsen Research Centre, Canada
Although different antiplatelet agents are used for the prevention of thrombosis and treatment of ischemic heart disease, very little information regarding therapeutic potential of these agents in heart failure is available. We have investigated the effects of some antiplatelet a [....] » Read More
Title : Advanced molecular and cellular mechanisms for pulmonary hypertension
Yong Xiao Wang, Albany Medical Center, United States
Pulmonary hypertension (PH) is a common and devastating lung disease. The current primary interventions for this disease are to use non-specific vasodilators, but patients do not always respond well to these non-specific vasodilators. Voltage-dependent potassium channels and stor [....] » Read More
Title : Autoimmunity to GRP78 is associated with atherosclerosis in COPD patients, and a pilot trial of autoimmune therapy with belimumab
Duncan Steven R, University of Alabama at Birmingham, United States
Atherosclerotic cardiovascular disease (CVD) is the single greatest cause of death in patients with chronic obstructive pulmonary disease (COPD). The prevalence of CVD in this population exceeds that attributable to traditional risk factors (hypertension, age, smoking hyperlipide [....] » Read More
Title : Left atrial appendage occlusion during cardiac surgery to prevent stroke: A systematic review and meta-analysis
Alaa A Sayed, UPMC, United States
Introduction: Atrial fibrillation accounts for one-sixth of all strokes, potentially leading to significant disability and death. The left atrial appendage (LAA) is the most common location for thrombus formation that can cause ischemic strokes. Excluding the LAA has been hypothe [....] » Read More
Title : Heroic measures: Mechanical circulatory support with VA-ECMO in acute MI complicated by cardiogenic shock
Mukta Srivastava, University of Maryland School of Medicine, United States
Cardiogenic shock in the context of acute myocardial infarction (AMI-CS) remains a highly morbid presentation with high associated mortality, despite significant advances in early institution of reperfusion and multiple available modalities for mechanical circulatory support. Con [....] » Read More
Title : Insulin resistance spawns hypertriglyceridemia-induced acute pancreatitis and diabetic ketoacidosis: Unboxing a new metabolic crisis
Chaoneng Wu, Michigan State University, United States
Introduction: Insulin resistance (IR) means defective insulin stimulated glucose uptake accompanied by impaired insulin induced suppression of hepatic glucose output. Hypertriglyceridemia (HTG) constitutes a critical component of metabolic syndrome, which includes obesity, H [....] » Read More
Title : Optimal adoption of the CNIC-polypill strategy (acetyl salicylic acid, atorvastatin and ramipril) in routine clinical practice: Global expert consensus and endorsement for enhanced cardiovascular outcomes
Jose Maria Castellano Vazquez, National Center for Cardiovascular Research (CNIC), Spain
Background: The incidence of recurrent cardiovascular (CV) events (CVe) and all-cause mortality is high among patients in secondary prevention. The SECURE trial demonstrated that the CNIC-Polypill Strategy combining acetylsalicylic acid [ASA], atorvastatin and ramipril into a sin [....] » Read More
Title : Safety and efficacy of chlorthalidone vs hydrochlorothiazide in hypertension
Jaykaran Charan, All India Institute of Medical Sciences, India
Hypertension is associated with an increased risk of complications and deaths from cardiovascular diseases. Thiazide diuretics, one of the first-line drugs for hypertension, include chlorthalidone and hydrochlorothiazide. This systemic review and meta-analysis aim to analyze the [....] » Read More
Title : Exploring a therapeutic dilemma: A case study of bilateral renal artery stenosis induced by aortoarteritis manifesting as a hypertensive emergency
Tutan Das, Vivekananda Hospital, India
Introduction: Hypertensive emergencies present diagnostic and therapeutic challenges, particularly in young patients. We present a compelling case of a 23-year-old female presenting with refractory hypertensive emergency, ultimately diagnosed with bilateral renal artery stenosis [....] » Read More
Title : Hypertrophic cardiomyopathy contemporary outcomes of family screening and the necessity of whole exome sequencing in Indian sub-continent
Ansh Goswami, AIIMS, India
Background and Aim: Hypertrophic cardiomyopathy (HCM) is one of the common and primary genetic cardiomyopathy characterized by inappropriate hypertrophy of the interventricular septum and ventricle with variable clinical presentations, one of the commonest being sudden cardi [....] » Read More
Title : Gender diffrence and its outcomes in anemic patients undergoing CABG
Muhammad Wasim Sajjad, Rehman Medical Institute, Pakistan
Background: According to some studies female gender is considered as independent predictor of mortality in CABG. We sought to further identify the impact of anemia on outcomes according to gender. Material & methods: The observational study on retrospective data was conduc [....] » Read More
Title : Cardiac autonomic neuropathy: Impact on severe hypoglycemic unawareness and orthostatic hypotension in diabetic dysautonomia- A case series study
Chaoneng Wu, Michigan State University, United States
Introduction: Diabetic autonomic neuropathy (DAN) impacts cardiovascular health with an increasing prevalence over diabetic course, affecting up to 50% of patients after 15 years. Notably, DAN-associated cardiovascular autonomic neuropathy (CAN) have a mortality rate of 16% to 50 [....] » Read More
Title : Hybrid approach of photon-counting computed tomography and intravascular ultrasound for chest pain: A case report of successful management and 6-month follow up
Chinh Duc Nguyen, Can Tho Stroke International Services, Vietnam
Introduction: Coronary artery disease is the leading cause of death among non-communicable diseases. Management stragedy emphasizes on early detection and optimal treatment, with emerging roles of imaging approaches. Photon-couting computed tomography is a new non-invasive diagno [....] » Read More
Title : A novel technology to treat and reverse moderate/servere heart failure to NYHA I-II using electrical microcurrent
Johannes Mueller, Berlin Heals, Germany
Device-based therapy for heart failure is essentially based on two systems available on the market and has only limited long-term success. The basis of these systems is the delivery of different electrical pulses to the myocardium. Based on the knowledge that physiologically cons [....] » Read More
Title : Transcatheter aortic valve implantation (TAVI): Assumptions about the possible occurrence of new cardiac conduction disorders
Valeriya S Chekanova, National Medical Research Centre of Cardiology Named After Academician , Russian Federation
Introduction: Aortic stenosis is a pathology with a constantly progressive course. For patients at high surgical risk, transcatheter aortic valve implantation (TAVI) is the method of choice. Nevertheless, cardiac conduction disturbances occur in 6–65% of cases. The mo [....] » Read More
Title : Treatment of atrio-esophageal fistula following epicardial ablation for atrial fibrillation
David W Yaffee, Hartford HealthCare, United States
Atrio-esophageal fistula is a rare but life-threatening complication of epicardial atrial ablation. Concomitant surgical repair of the heart and esophagus carries a high morbidity and mortality, especially when repair is attempted without cardiopulmonary bypass. We report the pre [....] » Read More
Title : A case of amaurosis fugax, infectious or embolic?
Alaa A Sayed, UPMC, United States
The patient is a 54-year-old female with past medical history of Dilation and curettage (D&C) who presented with left sided monocular vision loss 5 months prior to admission. She was evaluated by stroke with comprehensive workup that has been negative. She obtained TTE was si [....] » Read More
Title : The Underrepresented: A rare form of hypertrophic cardiomyopathy
Cynthia Okafor, University of Texas Medical Branch, United States
Hypertrophic cardiomyopathy is a disease of the myocardium with an autosomal dominant inheritance pattern. Its primary cause is a mutation in the cardiac sarcomere proteins with contractile function. A defining feature and major hallmark of the disease is a left ventricular obstr [....] » Read More
Title : Coronary cameral fistula from the left circumflex artery to the left ventricle contributing to heart failure: A case report
Lianne Marie R Ramos, Cardinal Santos Medical Center, Philippines
Coronary cameral fistulae are occasionally incidental findings present in less than 1% of the population and 0.1%-0.2% of coronary angiographic studies. In children, coronary artery fistulae account for around half of coronary vasculature anomalies. Most commonly, these drain fro [....] » Read More
Title : Genetic landscape of restrictive cardiomyopathy: A study of 40 cases from North India
Sudheer Arava, AIIMS, New Delhi, India
Background and Aim: Restrictive cardiomyopathy is one of the rarest types of cardiomyopathy with a prevalence of 1: 1500-2000 in USA. Clincioradiologicaly, it is characterized by normal ventricles, dilated atrial chambers with diastolic dysfunction. Many secondary etiologica [....] » Read More
Title : Impact of percutaneous coronary intervention on renal function in patients with coronary heart disease
Bing Ji, Tongji University, China
There is a complex relationship between cardiac and renal function. The effect of the percutaneous coronary intervention (PCI) on the renal function in patients with coronary artery disease remains poorly understood. The aim of the present study was to assess renal function chang [....] » Read More
Title : Frequencies of genes polymorphisms associated with warfarin dosage in the Kazakh population
Alexandra Murtazaliyeva, JSC “Scientific Center of Obstetrics, Gynecology and Perinatology”, Kazakhstan
Introduction: Statistics show that about 10,000 open heart surgeries are performed in Kazakhstan, with more than 3,000 patients with acquired heart defects. Warfarin is the primary oral anticoagulant to prevent complications after surgery in Kazakhstan. Most studie [....] » Read More
Title : Primary arterial switch operation in late presentation of transposition of the great arteries
Molka Louati, Hedi Chaker University Hospital, Tunisia
Introduction : Transposition of the great arteries (TGA) with intact ventricular septum (IVS) are subject to neonatal arterial switch operation (ASO) to avoid deconditioning of the left ventricle (LV). Often an early repair is not feasible in developing countries where la [....] » Read More
Title : Molecular basis of modulation of the vascular TMEM16A channel by GPCR pathways: Therapeutic potential for control of artery tone
Catherine Choi, University of Oxford, United Kingdom
Introduction: The TMEM16A channel is a Ca2+-activated Cl- channel (CaCC) highly expressed in mammalian arterial smooth muscle. The channel connects Ca2+ release triggered by Gq protein-coupled receptor (GqPCR) activation with membrane depolarisation and smooth muscle contraction. [....] » Read More
Title : Exploring the relationship between erythrocyte aggregation properties and sodium homeostasis in subjects with arterial hypertension
Shreeya Mehta, King’s College London, United Kingdom
Introduction: Hypertension is the primary preventable factor contributing to premature mortality and disability on a global scale – and a major risk factor for cardiovascular disease. ~ 50% of patients present with a ‘salt-sensitive’ hypertensive phenotype. Alon [....] » Read More
Title : Glucocorticoids alleviate inflammation but do not improve left ventricular diastolic dysfunction in collagen-induced arthritic rats
Lebogang Mokotedi, Sefako Makgatho Health Sciences University, South Africa
Background: Systemic inflammation in rheumatoid arthritis (RA) significantly contributes to left ventricular (LV) diastolic dysfunction. Although glucocorticoids (GCs) are effective in managing RA inflammation, their long-term use may affect cardiovascular disease risk. There is [....] » Read More
Title : How reliable is CTCA in diagnosis of prognostically significant coronary artery disease?
Dimitrios Nasiakos, University of Exeter Medical School, United Kingdom
Coronary artery disease (CAD) remains a leading cause of mortality worldwide, posing significant challenges to healthcare systems. CT coronary angiography (CTCA) has emerged as the preferred initial diagnostic tool for stable angina due to its non-invasive nature and high sensiti [....] » Read More