Kaifu Chen, Boston Children’s Hospital, United States
A cell type is determined by the network function of its cell identity genes, including master transcription factors that govern the expression status of this network. Cell identity transition is fundamental in normal differentiation and development, whereas a cell that loses its [....] » Read More
Title : Antiplatelet agents as a novel therapy of heart failure due to myocardial infarction
Naranjan S Dhalla, St. Boniface Hospital Albrechtsen Research Centre, Canada
Although different antiplatelet agents are used for the prevention of thrombosis and treatment of ischemic heart disease, very little information regarding therapeutic potential of these agents in heart failure is available. We have investigated the effects of some antiplatelet a [....] » Read More
Title : Advanced molecular and cellular mechanisms for pulmonary hypertension
Yong Xiao Wang, Albany Medical Center, United States
Pulmonary hypertension (PH) is a common and devastating lung disease. The current primary interventions for this disease are to use non-specific vasodilators, but patients do not always respond well to these non-specific vasodilators. Voltage-dependent potassium channels and stor [....] » Read More
Title : Autoimmunity to GRP78 is associated with atherosclerosis in COPD patients, and a pilot trial of autoimmune therapy with belimumab
Duncan Steven R, University of Alabama at Birmingham, United States
Atherosclerotic cardiovascular disease (CVD) is the single greatest cause of death in patients with chronic obstructive pulmonary disease (COPD). The prevalence of CVD in this population exceeds that attributable to traditional risk factors (hypertension, age, smoking hyperlipide [....] » Read More
Title : Left atrial appendage occlusion during cardiac surgery to prevent stroke: A systematic review and meta-analysis
Alaa A Sayed, UPMC, United States
Introduction: Atrial fibrillation accounts for one-sixth of all strokes, potentially leading to significant disability and death. The left atrial appendage (LAA) is the most common location for thrombus formation that can cause ischemic strokes. Excluding the LAA has been hypothe [....] » Read More
Title : Heroic measures: Mechanical circulatory support with VA-ECMO in acute MI complicated by cardiogenic shock
Mukta Srivastava, University of Maryland School of Medicine, United States
Cardiogenic shock in the context of acute myocardial infarction (AMI-CS) remains a highly morbid presentation with high associated mortality, despite significant advances in early institution of reperfusion and multiple available modalities for mechanical circulatory support. Con [....] » Read More
Title : Insulin resistance spawns hypertriglyceridemia-induced acute pancreatitis and diabetic ketoacidosis: Unboxing a new metabolic crisis
Chaoneng Wu, Michigan State University, United States
Introduction: Insulin resistance (IR) means defective insulin stimulated glucose uptake accompanied by impaired insulin induced suppression of hepatic glucose output. Hypertriglyceridemia (HTG) constitutes a critical component of metabolic syndrome, which includes obesity, H [....] » Read More
Title : Optimal adoption of the CNIC-polypill strategy (acetyl salicylic acid, atorvastatin and ramipril) in routine clinical practice: Global expert consensus and endorsement for enhanced cardiovascular outcomes
Jose Maria Castellano Vazquez, National Center for Cardiovascular Research (CNIC), Spain
Background: The incidence of recurrent cardiovascular (CV) events (CVe) and all-cause mortality is high among patients in secondary prevention. The SECURE trial demonstrated that the CNIC-Polypill Strategy combining acetylsalicylic acid [ASA], atorvastatin and ramipril into a sin [....] » Read More
Title : Safety and efficacy of chlorthalidone vs hydrochlorothiazide in hypertension
Jaykaran Charan, All India Institute of Medical Sciences, India
Hypertension is associated with an increased risk of complications and deaths from cardiovascular diseases. Thiazide diuretics, one of the first-line drugs for hypertension, include chlorthalidone and hydrochlorothiazide. This systemic review and meta-analysis aim to analyze the [....] » Read More
Title : Exploring a therapeutic dilemma: A case study of bilateral renal artery stenosis induced by aortoarteritis manifesting as a hypertensive emergency
Tutan Das, Vivekananda Hospital, India
Introduction: Hypertensive emergencies present diagnostic and therapeutic challenges, particularly in young patients. We present a compelling case of a 23-year-old female presenting with refractory hypertensive emergency, ultimately diagnosed with bilateral renal artery stenosis [....] » Read More
Title : Hypertrophic cardiomyopathy contemporary outcomes of family screening and the necessity of whole exome sequencing in Indian sub-continent
Ansh Goswami, AIIMS, India
Background and Aim: Hypertrophic cardiomyopathy (HCM) is one of the common and primary genetic cardiomyopathy characterized by inappropriate hypertrophy of the interventricular septum and ventricle with variable clinical presentations, one of the commonest being sudden cardi [....] » Read More
Title : Gender diffrence and its outcomes in anemic patients undergoing CABG
Muhammad Wasim Sajjad, Rehman Medical Institute, Pakistan
Background: According to some studies female gender is considered as independent predictor of mortality in CABG. We sought to further identify the impact of anemia on outcomes according to gender. Material & methods: The observational study on retrospective data was conduc [....] » Read More
Title : Cardiac autonomic neuropathy: Impact on severe hypoglycemic unawareness and orthostatic hypotension in diabetic dysautonomia- A case series study
Chaoneng Wu, Michigan State University, United States
Introduction: Diabetic autonomic neuropathy (DAN) impacts cardiovascular health with an increasing prevalence over diabetic course, affecting up to 50% of patients after 15 years. Notably, DAN-associated cardiovascular autonomic neuropathy (CAN) have a mortality rate of 16% to 50 [....] » Read More
Title : Hybrid approach of photon-counting computed tomography and intravascular ultrasound for chest pain: A case report of successful management and 6-month follow up
Chinh Duc Nguyen, Can Tho Stroke International Services, Vietnam
Introduction: Coronary artery disease is the leading cause of death among non-communicable diseases. Management stragedy emphasizes on early detection and optimal treatment, with emerging roles of imaging approaches. Photon-couting computed tomography is a new non-invasive diagno [....] » Read More
Title : A novel technology to treat and reverse moderate/servere heart failure to NYHA I-II using electrical microcurrent
Johannes Mueller, Berlin Heals, Germany
Device-based therapy for heart failure is essentially based on two systems available on the market and has only limited long-term success. The basis of these systems is the delivery of different electrical pulses to the myocardium. Based on the knowledge that physiologically cons [....] » Read More
Title : Transcatheter aortic valve implantation (TAVI): Assumptions about the possible occurrence of new cardiac conduction disorders
Valeriya S Chekanova, National Medical Research Centre of Cardiology Named After Academician , Russian Federation
Introduction: Aortic stenosis is a pathology with a constantly progressive course. For patients at high surgical risk, transcatheter aortic valve implantation (TAVI) is the method of choice. Nevertheless, cardiac conduction disturbances occur in 6–65% of cases. The mo [....] » Read More
Title : Treatment of atrio-esophageal fistula following epicardial ablation for atrial fibrillation
David W Yaffee, Hartford HealthCare, United States
Atrio-esophageal fistula is a rare but life-threatening complication of epicardial atrial ablation. Concomitant surgical repair of the heart and esophagus carries a high morbidity and mortality, especially when repair is attempted without cardiopulmonary bypass. We report the pre [....] » Read More
Title : A case of amaurosis fugax, infectious or embolic?
Alaa A Sayed, UPMC, United States
The patient is a 54-year-old female with past medical history of Dilation and curettage (D&C) who presented with left sided monocular vision loss 5 months prior to admission. She was evaluated by stroke with comprehensive workup that has been negative. She obtained TTE was si [....] » Read More
Title : The Underrepresented: A rare form of hypertrophic cardiomyopathy
Cynthia Okafor, University of Texas Medical Branch, United States
Hypertrophic cardiomyopathy is a disease of the myocardium with an autosomal dominant inheritance pattern. Its primary cause is a mutation in the cardiac sarcomere proteins with contractile function. A defining feature and major hallmark of the disease is a left ventricular obstr [....] » Read More
Title : Coronary cameral fistula from the left circumflex artery to the left ventricle contributing to heart failure: A case report
Lianne Marie R Ramos, Cardinal Santos Medical Center, Philippines
Coronary cameral fistulae are occasionally incidental findings present in less than 1% of the population and 0.1%-0.2% of coronary angiographic studies. In children, coronary artery fistulae account for around half of coronary vasculature anomalies. Most commonly, these drain fro [....] » Read More
Title : Genetic landscape of restrictive cardiomyopathy: A study of 40 cases from North India
Sudheer Arava, AIIMS, New Delhi, India
Background and Aim: Restrictive cardiomyopathy is one of the rarest types of cardiomyopathy with a prevalence of 1: 1500-2000 in USA. Clincioradiologicaly, it is characterized by normal ventricles, dilated atrial chambers with diastolic dysfunction. Many secondary etiologica [....] » Read More
Title : Impact of percutaneous coronary intervention on renal function in patients with coronary heart disease
Bing Ji, Tongji University, China
There is a complex relationship between cardiac and renal function. The effect of the percutaneous coronary intervention (PCI) on the renal function in patients with coronary artery disease remains poorly understood. The aim of the present study was to assess renal function chang [....] » Read More
Title : Frequencies of genes polymorphisms associated with warfarin dosage in the Kazakh population
Alexandra Murtazaliyeva, JSC “Scientific Center of Obstetrics, Gynecology and Perinatology”, Kazakhstan
Introduction: Statistics show that about 10,000 open heart surgeries are performed in Kazakhstan, with more than 3,000 patients with acquired heart defects. Warfarin is the primary oral anticoagulant to prevent complications after surgery in Kazakhstan. Most studie [....] » Read More
Title : Primary arterial switch operation in late presentation of transposition of the great arteries
Molka Louati, Hedi Chaker University Hospital, Tunisia
Introduction : Transposition of the great arteries (TGA) with intact ventricular septum (IVS) are subject to neonatal arterial switch operation (ASO) to avoid deconditioning of the left ventricle (LV). Often an early repair is not feasible in developing countries where la [....] » Read More
Title : Molecular basis of modulation of the vascular TMEM16A channel by GPCR pathways: Therapeutic potential for control of artery tone
Catherine Choi, University of Oxford, United Kingdom
Introduction: The TMEM16A channel is a Ca2+-activated Cl- channel (CaCC) highly expressed in mammalian arterial smooth muscle. The channel connects Ca2+ release triggered by Gq protein-coupled receptor (GqPCR) activation with membrane depolarisation and smooth muscle contraction. [....] » Read More
Title : Exploring the relationship between erythrocyte aggregation properties and sodium homeostasis in subjects with arterial hypertension
Shreeya Mehta, King’s College London, United Kingdom
Introduction: Hypertension is the primary preventable factor contributing to premature mortality and disability on a global scale – and a major risk factor for cardiovascular disease. ~ 50% of patients present with a ‘salt-sensitive’ hypertensive phenotype. Alon [....] » Read More
Title : Glucocorticoids alleviate inflammation but do not improve left ventricular diastolic dysfunction in collagen-induced arthritic rats
Lebogang Mokotedi, Sefako Makgatho Health Sciences University, South Africa
Background: Systemic inflammation in rheumatoid arthritis (RA) significantly contributes to left ventricular (LV) diastolic dysfunction. Although glucocorticoids (GCs) are effective in managing RA inflammation, their long-term use may affect cardiovascular disease risk. There is [....] » Read More
Title : How reliable is CTCA in diagnosis of prognostically significant coronary artery disease?
Dimitrios Nasiakos, University of Exeter Medical School, United Kingdom
Coronary artery disease (CAD) remains a leading cause of mortality worldwide, posing significant challenges to healthcare systems. CT coronary angiography (CTCA) has emerged as the preferred initial diagnostic tool for stable angina due to its non-invasive nature and high sensiti [....] » Read More