Title : Effects of the ketogenic diet and intermittent fasting on systolic blood pressure and vascular reactivity in a cohort of women with obesity and blood hypertension (DIET-TO-HTN): baseline characteristics.
Cardiovascular disease is the leading cause of mortality for women and is responsible for 35% of total deaths in women, since there is a growing interest (as the Lancet Commission alert) on reducing the global burden of cardiovascular disease. It is estimated that obesity contributes significantly to women cardiovascular disease prevalence and mortality and should be considered a target for health interventions. Obesity is prevalent and increasing globally; moreover, together with insufficient physical activity, is closely associated with hypertension, and is more prevalent in women than in men. Analyses of US National Health and Nutrition Examination Survey data have identified obesity as the most important modifiable risk factor for hypertension. Women appear to have a higher risk of acute myocardial infarction associated with the occurrence of hypertension than men have, as reported from the INTERHEART study. Central obesity, which is a key feature of metabolic syndrome, affects women after menopause, when hormonal changes cause profound metabolic changes and increase the probability of the onset of cardiovascular disease.