Title : Outcomes of tricuspid valve clipping for severe tricuspid regurgitation: A systematic review
Abstract:
Introduction: Tricuspid regurgitation (TR) is a common valvular disease linked to significant morbidity and mortality. It has a well-documented independent prognostic impact. Surgical repair (SR) is a recognized option for severe or progressive TR, or as an adjunct to mitral valve surgery; however, it is infrequently performed due to associated risks. Transcatheter interventions, particularly TR clipping, have emerged as a promising minimally invasive alternative for patients with symptomatic moderate to severe TR.
Method: Pubmed, embase and cochrane databases were searched using keywords “Tricuspid clipping” AND “outcomes” from 1998 to 2024. All the relevant observational studies were included. Outcomes studied are reduction in TR grade by at least one point, all cause mortality and effect of concomitant MR.
Results: Six relevant observational studies (N = 492) were included in the systematic review. Out of the N = 492 patients who underwent clipping for TR, N = 407 patients showed a reduction in TR grade by at least one point which subsequently corresponded to a reduction in NYHA class and clinical improvement. All cause mortality at one year post-procedure was N = 57 out of 432 patients who underwent TR clipping. 195 out of 403 patients had both tricuspid and mitral disease.
Conclusion: Our analysis indicates that TR clipping is a viable therapeutic option, particularly for patients with severe TR, even in the presence of concomitant mitral valve disease. Further research is needed to establish long-term outcomes and optimize patient selection criteria.
