The human ether-a-go-go–related gene (hERG) encodes the potassium channel Kv11.1 (commonly known as hERG) that conducts the rapidly activating delayed rectifier potassium current (IKr). Normal function of hERG is critical for cardiac repolarization and its dysfunction cause [....] » Read More
Motivation of the Work: Identification of barriers in enrolling patients, identification of risk factors, compliance and adherence to treatment and lifestyle changes proposed by specialists Compliance, the patient's behavioral response to the lifestyle change and the prescrib [....] » Read More
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are principally known as agents for the control of Type 2 diabetes mellitus (Type 2 DM). In recent years, they have gained more attention, especially for their role in cardiovascular protection in Type 2 diabetes patie [....] » Read More
Introduction: In the realm of percutaneous coronary intervention (PCI), the management of coronary artery calcium poses a significant challenge, particularly in cases of severe calcification and high-risk patients. Inadequate addressal leads to suboptimal outcomes in terms of ste [....] » Read More
Introduction: STEMI mimickers have been described in literature for many decades, but each clinical interaction teaches us new ways to tackle these medical emergencies. This case underscores the need to individualize every case in an effort to avoid delaying life-saving treatment [....] » Read More
The symptoms shown by frail patients with heart failure (HF) are sometimes different and the most common symptoms may be absent, delaying the diagnosis and finding patients with more severe HF. The use of lung ultrasound in these patients could help to objectify real congestion.& [....] » Read More
Background and Aim Restrictive cardiomyopathy is one of the rarest types of cardiomyopathy with a prevalence of 1: 1500-2000 in USA. Clincioradiologicaly, it is characterized by normal ventricles, dilated atrial chambers with diastolic dysfunction. Many secondary etiological f [....] » Read More
Background and Aim: Hypertrophic cardiomyopathy (HCM) is one of the common and primary genetic cardiomyopathy characterized by inappropriate hypertrophy of the interventricular septum and ventricle with variable clinical presentations, one of the commonest being sudden cardi [....] » Read More
Introduction: ASD has a generally good prognosis and if left untreated can lead to PH. The present study was conducted to determine the predictors of treatment success among adult ASD with PH and develop a scoring system based on the identified factors. Methods: Adult patients wi [....] » Read More
Background: The aorta can be involved in different pathologies, including congenital, syndromic, and acquired disorders, which may need intervention in any form to prevent disasters. The purpose of this study was to review the types of aortic pathologies treated surgically and th [....] » Read More
Device-based therapy for heart failure is essentially based on two systems available on the market and has only limited long-term success. The basis of these systems is the delivery of different electrical pulses to the myocardium. Based on the knowledge that physiologically cons [....] » Read More
LVAD Therapy has become a safe and successful long-term therapy for patients with advanced heart failure. Off the shelf 24/7 availability allows to treat patients, when necessary, in time. Significant reduction of anticoagulation therapy in recent years has allowed to reduce blee [....] » Read More
Human relaxin-2 (hRlx-2) is a hormone of pregnancy that has engendered a great deal of interest as a therapy for various cardiovascular and inflammatory diseases, among them Acute Heart Failure and Systemic Scleroderma. Here, we propose and summarize data showing that Rlx-2 repre [....] » Read More
Aim: The aim of the study is to analyze the risk of cardiovascular complications (CVC) in an unorganized population of men and women of working age in the Vladimir region. Material and methods: The cross-sectional population-based study included 1,350 men and women aged 3 [....] » Read More
Objective: To assess the association between maternal congenital heart disease (CHD) and adverse neonatal outcomes, focusing on birth weight, gestational age, Apgar scores, and neonatal intensive care unit (NICU) admissions. Study Design: A retrospective cohort study span [....] » Read More
Atherothrombotic disease, characterized by the formation of atherosclerotic plaques leading to arterial thrombosis, is a significant cause of morbidity and mortality worldwide. Despite considerable progress in therapeutic interventions, there remains an unmet need for novel treat [....] » Read More
The potential applications of generative AI in the field of cardiology are remarkably broad. Recent research suggests that generative AI is expected to bring a wide range of innovations across the diagnosis and management of cardiovascular diseases. Particularly, the use of gener [....] » Read More
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. The disruption of the hepatic interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and Low-Density Lipoprotein Receptor (LDLR) downr [....] » Read More
Background: Serum uric acid (sUA) has been known to be associated with an increased risk of developing cardiovascular disease in different populations. However, whether this is also the case with Nigerian patients remains understudied. The study aimed to assess the associatio [....] » Read More
In recent years, wearables are exploding in popularity as unobtrusive devices able to extend traditional healthcare delivery systems. Smart textiles are one of the main innovative types of wearables used for non invasive and continuous monitoring of cardiac activity. A prominent [....] » Read More
Background: Pompe disease is an autosomal recessive lysosomal storage disorder characterized by progressive myopathy with proximal muscle weakness, respiratory muscle dysfunction, and cardiomyopathy. Its prevalence ranges between 1/9000 and 1/40,000. It is caused by compound hete [....] » Read More
Rationale: Mesocardia is the heart in the middle compartment of the chest. The human heart is normally located within the thoracic cavity, medially between the lungs in the mediastinum. Marfan syndrome is an autosomal dominant disorder and multi-systemic genetic disorder that [....] » Read More
Introduction: An understanding of the association between apolipoprotein B (Apo-B) and CRP (C-reactive protein) in the development of residual cardiovascular risk is very important when comparing it with atherogenic lipoproteins such as HDL-cholesterol, LDL-cholesterol. Apol [....] » Read More
PFO is one of the most common congenital heart diseases and fluoroscopic percutaneous closure devices based on non-degradable alloys have been widely used in clinical application and saved numerous patients but some developed countries using biodegradable closure devices un [....] » Read More
Smoking is considered a chronic disease caused by chemical dependence of nicotine. This is highly addicting, it in the brain system it influences our emotions, increases the feeling of pleasure/humor and reduces the anxiety. In a planet with about 8 billion people, around 1, [....] » Read More
Chronic pain is defined as persistent pain for more than three months and can be classified as primary with no known etiology, or secondary pertinent to a pathological process and specific clinical diagnosis.In previous studies, we observed that it directly impacts cardiac rehabi [....] » Read More
Background: Univentricular heart (UH) is a rare congenital heart malformation, characterized by the absence of two well-developed ventricles and the presence of a single functional ventricle. In these cases, cardiac magnetic resonance imaging or catheterization can be used for pr [....] » Read More
Cardiac myocytes originating from different parts of the heart exhibit varying morphology and ultrastructure. However, the difference in their dynamic behavior is unclear. We examined the contraction of cardiac myocytes originating from the apex, ventricle, and atrium, and found [....] » Read More
This study aimed to examine the cardiometabolic index during early pregnancy in individuals with hypertension-complicating pregnancy, especially preeclampsia. Additionally, this study sought to determine the relationship between cardiometabolic index and the incidence of varying [....] » Read More
The presentation will focus on the treatment and comprehensive management of Cardiorenal Syndrome (CRS) in the acute hospital setting, which is characterized by acute kidney injury resulting from acute decompensated heart failure. Various therapeutic strategies will be discussed& [....] » Read More
This study aimed to examine the cardiometabolic index during early pregnancy in individuals with hypertension-complicating pregnancy, especially preeclampsia. Additionally, this study sought to determine the relationship between cardiometabolic index and the incidence of varying [....] » Read More
Background: Approximately 20.1 million adults in the United States are affected by coronary artery disease. Every year over 4 million coronary angiograms are being performed in Europe and the USA. Over 1700 cardiac catheterization laboratories were present across the United [....] » Read More
Objective: This study aims to provide an overview of recent research advancements in personalized care for tracheostomy patients and explore how personalized care can enhance the quality of life for patients with long-term tracheostomy. Methods and Materials: Through lit [....] » Read More
Objective: To investigate the changes of serum lipoprotein-associated phospholipase A2 (Lp-PLA2), Soluble suppression of tumorigenicity 2 (sST2) and microcirculatory resistance reserve index (MRR) in patients with ST segment elevation myocardial infarction (STEMI) after percutane [....] » Read More
Background: Hypercholesterolaemia and poor blood glucose control are well known risk factors for developing myocardial infarction (MI). Preventative measures have been incorporated into several guidelines around the world. We aim to review our performance in adhering to the [....] » Read More
Background: Cardiovascular diseases are the world’s number one cause of death. Various scoring systems and indicators, biochemical and otherwise, have arisen to help estimate the cardiovascular risk of populations, thus helping with screening and implementing measures to at [....] » Read More
Background: The New York Heart Association (NYHA) classification system is a subjective assessment tool used by physicians to evaluate the functional status of patients. In the era of novel pharmacologic treatments for hypertrophic obstructive cardiomyopathy (HOCM), it is c [....] » Read More
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Title : Antiplatelet agents as a novel therapy of heart failure due to myocardial infarction
Naranjan S Dhalla, St. Boniface Hospital Albrechtsen Research Centre, Canada
Although different antiplatelet agents are used for the prevention of thrombosis and treatment of ischemic heart disease, very little information regarding therapeutic potential of these agents in heart failure is available. We have investigated the effects of some antiplatelet a [....] » Read More
Title : Advanced molecular and cellular mechanisms for pulmonary hypertension
Yong Xiao Wang, Albany Medical Center, United States
Pulmonary hypertension (PH) is a common and devastating lung disease. The current primary interventions for this disease are to use non-specific vasodilators, but patients do not always respond well to these non-specific vasodilators. Voltage-dependent potassium channels and stor [....] » Read More
Title : Coronary Artery Abnormalities in Children
Kumar Ponniah, Wolfson Terry Heart Institute, United States
Coronary artery abnormalities whether congenital or acquired are an important cause of morbidity and mortality in Children. The current talk will focus on Congenital coronary abnormalities as well acquired coronary disease i.e., Kawasaki disease in children. Coronary Artery An [....] » Read More
Title : Cardiometry: A new fundamental scientific field in cardiology
David Tamrazyan, Krasnodar State University, Spain
Cardiometry is a new basic science that will make the diagnosis of cardiovascular pathology easier, cheaper and faster. New perspectives in the study of the hemodynamics of the organism. Cardiometry gives us the opportunity to see the functioning of our body from a different pers [....] » Read More
Title : Optimal adoption of the CNIC-polypill strategy (acetyl salicylic acid, atorvastatin and ramipril) in routine clinical practice: Global expert consensus and endorsement for enhanced cardiovascular outcomes
Jose Maria Castellano Vazquez, National Center for Cardiovascular Research (CNIC), Spain
Background: The incidence of recurrent cardiovascular (CV) events (CVe) and all-cause mortality is high among patients in secondary prevention. The SECURE trial demonstrated that the CNIC-Polypill Strategy combining acetylsalicylic acid [ASA], atorvastatin and ramipril into a sin [....] » Read More
Title : Deciphering the mind-heart mystery : A case report on 16-year-old’s struggle with unexplained dizziness and non-exertion syncope
Gurkamal Sohal, University Hospitals Birmingham NHS Foundation Trust, United Kingdom
This 16-year-old male presented by recurrent dizziness, escalating to blank spells resulting in sudden, non-exertion-related syncope. Despite extensive medical evaluations including normal clinical examination, blood pressure readings (lying and standing), EEG, resting ECG, echoc [....] » Read More
Title : Insulin resistance spawns hypertriglyceridemia-induced acute pancreatitis and diabetic ketoacidosis: Unboxing a new metabolic crisis
Chaoneng Wu, Michigan State University, United States
Introduction: Insulin resistance (IR) means defective insulin stimulated glucose uptake accompanied by impaired insulin induced suppression of hepatic glucose output. Hypertriglyceridemia (HTG) constitutes a critical component of metabolic syndrome, which includes obesity, H [....] » Read More
Title : Hybrid approach of photon-counting computed tomography and intravascular ultrasound for chest pain: A case report of successful management and 6-month follow up
Chinh Duc Nguyen, Can Tho Stroke International Services, Vietnam
Introduction: Coronary artery disease is the leading cause of death among non-communicable diseases. Management stragedy emphasizes on early detection and optimal treatment, with emerging roles of imaging approaches. Photon-couting computed tomography is a new non-invasive diagno [....] » Read More
Title : Complication in the treatment of atrial fibrillation in elderly patient with comorbidities
Veronika Kachmar, Jagiellonian University Medical College, Poland
Atrial fibrillation (AF) is the most common significant cardiac rhythm disorder and is also a powerful common risk factor for stroke: about 15% of all strokes in the U.S. are attributable to AF. The use of combined antiplatelet and anticoagulant therapy in patients with AF has re [....] » Read More
Title : Cardiac autonomic neuropathy: Impact on severe hypoglycemic unawareness and orthostatic hypotension in diabetic dysautonomia- A case series study
Chaoneng Wu, Michigan State University, United States
Introduction: Diabetic autonomic neuropathy (DAN) impacts cardiovascular health with an increasing prevalence over diabetic course, affecting up to 50% of patients after 15 years. Notably, DAN-associated cardiovascular autonomic neuropathy (CAN) have a mortality rate of 16% to 50 [....] » Read More
Title : Impact of virtual reality imaging on pre-operative planning for paediatric cardio surgery
Kelly Ka Yee Chu, East & North Hertfordshire NHS Trust, United Kingdom
Objectives: To investigate how virtual reality imaging impacts decision-making in atrioventricular valve surgery Methods: This was a single centre retrospective study involving 15 children and adolescents - median age 6 years (range 0.33 - 16) requiring surgica [....] » Read More
Title : Data analysis on the use of PCSK9 inhibitor (evolocumab – 140 mg/ml administered subcutaneously twice a month) in high cardiovascular risk patients with acute coronary syndrome undergoing coronary artery bypass grafting: A retrospective registry data analysis from January 2022 To July 2023
Giuseppe Nasso, Anthea Hospital GVM Care & Research, Italy
This presentation will discuss a retrospective analysis of the impact of administering the PCSK9 inhibitor evolocumab (140 mg/ml, subcutaneously twice a month) in addition to standard therapy (statins + ezetimibe) on LDL cholesterol levels and major adverse cardiovascular events [....] » Read More
Title : Exploring a therapeutic dilemma: A case study of bilateral renal artery stenosis induced by aortoarteritis manifesting as a hypertensive emergency
Tutan Das, Vivekananda Hospital, India
Introduction: Hypertensive emergencies present diagnostic and therapeutic challenges, particularly in young patients. We present a compelling case of a 23-year-old female presenting with refractory hypertensive emergency, ultimately diagnosed with bilateral renal artery stenosis [....] » Read More
Title : Frequencies of genes polymorphisms associated with warfarin dosage in the Kazakh population
Alexandra Murtazaliyeva, JSC “Scientific Center of Obstetrics, Gynecology and Perinatology”, Kazakhstan
Introduction: Statistics show that about 10,000 open heart surgeries are performed in Kazakhstan, with more than 3,000 patients with acquired heart defects. Warfarin is the primary oral anticoagulant to prevent complications after surgery in Kazakhstan. Most studie [....] » Read More
Title : Molecular basis of modulation of the vascular TMEM16A channel by GPCR pathways: Therapeutic potential for control of artery tone
Catherine Choi, University of Oxford, United Kingdom
Introduction: The TMEM16A channel is a Ca2+-activated Cl- channel (CaCC) highly expressed in mammalian arterial smooth muscle. The channel connects Ca2+ release triggered by Gq protein-coupled receptor (GqPCR) activation with membrane depolarisation and smooth muscle contraction. [....] » Read More
Title : Exploring the relationship between erythrocyte aggregation properties and sodium homeostasis in subjects with arterial hypertension
Shreeya Mehta, King’s College London, United Kingdom
Introduction: Hypertension is the primary preventable factor contributing to premature mortality and disability on a global scale – and a major risk factor for cardiovascular disease. ~ 50% of patients present with a ‘salt-sensitive’ hypertensive phenotype. Alon [....] » Read More
Title : Treatment of atrio-esophageal fistula following epicardial ablation for atrial fibrillation
David W Yaffee, Hartford HealthCare, United States
Atrio-esophageal fistula is a rare but life-threatening complication of epicardial atrial ablation. Concomitant surgical repair of the heart and esophagus carries a high morbidity and mortality, especially when repair is attempted without cardiopulmonary bypass. We report the pre [....] » Read More