3rd Edition of Cardiology World Conference

September 14-15, 2022 | Virtual Event

September 14 -15, 2022 | Online Event
Cardio 2022

To study the possibility of ape1/ref-1 as a novel biomarker in the detection of coronary artery disease

Neha Chandraker, Speaker at Cardiovascular Diseases Events
Banarsidas Chandiwala Institute of Medical Sciences, India
Title : To study the possibility of ape1/ref-1 as a novel biomarker in the detection of coronary artery disease

Abstract:

Coronary Artery Disease, is the leading cause of death globally resulting in over 7 million deaths. Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein that is mainly located in the nucleus. APE1 is involved in the base excision repair pathway, and Ref-1 acts as a reductive activator of many transcription factors in controlling different cellular process such as apoptosis, inflammation, proliferation, angiogenesis, and is involved in survival pathways. The study aimed to investigate the possibility of APE1/Ref-1 as a novel biomarker in the detection of Coronary Artery Disease in Indian population, and to correlate the levels of APE1/Ref-1, NT-proBNP and Lipid Profile in CAD patients. The study included 100 subjects divided into two groups of cases and controls. The Case group included Fifty patients diagnosed of Coronary Artery Disease based on Clinical findings with Electrocardiography, Biochemical Markers, Echocardiography and Angiogram(wherever possible) attending the hospital OPD. Fifty age and gender matched healthy individuals constituted the control group. Quantitative variables are expressed as mean±sd and compared between groups using Unpaired t-test/Mann-Whitney test.  Qualitative variables are expressed as frequencies/percentages and compared using Chi-square/Fisher’s Exact test. The mean APE 1 in case group was 3.77 ±1.03 whereas in control group was 1.20±0.7, with p-value of <0.001. A p value of <0.05 implies statistically significant difference in mean APE1 between case and control group. Our findings suggest that APE1/Ref-1 has a positive correlation with in patients of CAD. The study also suggest a positive correlation between  abnormal Lipid Profile, raised NT-proBNP, and APE1/Ref-1, which further supports that APE1/Ref-1 can in-turn become a positive biomarker in diagnosis and prognosis of CAD.

What will audience learn from your presentation?

  • Knowledge of APE1/Ref-1, a multifunctional protein
  • Open horizon for more in-depth research for development of a new novel bio-marker for CAD
  • Knowing the correlation of APE1/Ref-1, NT-proBNP and Lipid Profile in Coronary Artery Disease patients

Biography:

Dr Neha Chandrakar graduated MBBS from Dr D Y Patil Medical College, Mumbai, India in 2013. She completed her post graduation in the field of Ophthalmology from Venu Eye Institute & Research Centre, New delhi in 2017.
She then worked as a Senior Resident at All India Institute of Medical Sciences (AIIMS), Raipur till 2019. She received her fellowship degree in the sub-speciality of Oculoplasty in 2020. Currently, she is working as a Consultant at Chandiwala Hospital, New Delhi, India. She has published more than 10 research articles and case reports in various national and International journals.

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