HYBRID EVENT: You can participate in person at Madrid, Spain or Virtually from your home or work.

5th Edition of Cardiology World Conference

September 5-7, 2024 | Madrid, Spain

September 05 -07, 2024 | Madrid, Spain
Cardio 2022

Ronak Chhaya

Ronak Chhaya, Speaker at Cardiology Conferences
University of South Florida, United States
Title : Into the Wall: Left Ventricular Noncompaction


Left ventricular noncompaction (LVNC) is a rare, congenital disorder affecting the lining of myocardial tissue. This distinct phenotype includes blood-filled trabeculations and deep recesses in the uncompressed endocardial wall with a thin, compact mesocardium. Clinical presentation ranges from asymptomatic to heart failure, lethal arrhythmias and thromboembolism. A validated and accepted criteria for radiographic diagnosis describes the ratio of noncompacted to compacted myocardium >2:1. LVNC can be sporadic or familial, though specific environmental triggers have not clearly been established.

Case Presentation: 
A 22-year-old Hispanic male with history of end-stage renal disease secondary to glomerulonephritis, severe COVID-19 pneumonia and recent diffuse alveolar hemorrhage currently on prolonged glucocorticoid taper presented with acute heart failure. Echocardiogram demonstrated cardiomyopathy with left ventricular ejection fraction (LVEF) 35-40%, mild LV hypertrophy and moderate global hypokinesis. Lack of ischemic risk factors led to evaluation with cardiac MRI. Findings of mid-to-apical LV hypertrabeculation and noncompacted to compacted myocardial ratio of 3 were consistent with LV noncompaction. Arrhythmias or thromboembolic events were not observed. Guideline-directed medical therapy was initiated along with referral for genetic testing. 

Left ventricular noncompaction is an uncommon etiology of cardiomyopathy. Recognition is valuable due to known complications, including sudden cardiac death, arrhythmia and stroke. The pathogenesis underlying this young adult’s phenotype is not clearly identified. His symptoms developed in the setting of COVID-19 pneumonia, diffuse alveolar hemorrhage with significant anemia and prolonged steroid exposure. These correlates have not previously been described in association with LV noncompaction and their significance is unknown. 



Dr. Ronak Chhaya received his BS from the University of Michigan-Ann Arbor in 2012. He received his MA from Loyola University Chicago in 2013. He then spent several years at Michigan State University, receiving his MD in 2018 and completing Internal Medicine residency in 2021. He currently lives in Tampa, FL where he works as an academic hospitalist with the University of South Florida. He has long been engaged in research, notably living in Uganda for three months during medical school to lead HIV research. He has been published in peer-reviewed journals and presented at national conferences across the USA.