Title : Evaluating the Independent Impact of Renal Function Decline on Coronary Artery Calcification in Patients Undergone Cardiac CT Scan
Abstract:
Cardiovascular disease is the leading cause of death with most common etiology being coronary artery disease. Calcification in the intima and media layer of the vessel is of the first signs of of coronary artery involvement.
On the other hand, end stage renal disease have been shown to to result in vascular classification. Our study aimed to, firstly, investigate the association between renal function -in particular mild dysfunction- and, secondly, to determinate the role of this variable by eliminating the effect of confounding factors.
261 individuals -either asymptomatic or with atypical symptoms- having cardiovascular risk factors were studied by performing a CT scan without IV contrast. The images were interpreted by an experienced radiologist. The CAC score (Coronary Artery Calcification) was calculated with Agatston method; classified in 5 categories, ranging from none to severe calcification.
Medical history was gathered by questionnaire, a trained nurse recorded the demographic data and creatinine level for GFR estimation was collected from patients’ medical records. Multivariate and univariate analysis was performed. The results showed low eGFR as an independent risk factor for increased CAC among others.
What will audience learn from your presentation?
- Emphasizing on tight control of even mild kidney diseases to reduce future cardiovascular events
- Coronary calcification on CT scan images can be seen as an alarm sign for kidney disease
- We can use CAC score to determine the prognosis of cardiovascular events in patients with kidney involvement
- This study can be used as a basis for further investigations in CAC and kidney diseases
