Title : Choosing a suitable animal model for causing myocardial infarction
Abstract:
The diseases of cardiovascular are one of serious issues of the health. For applied objectives, medical researches should be according to scientific investigates on animals. Use an animal experimental model for myocardial infarction (MI) has specific importance. The differences in the cardiac structures between animals and human are which difficult to design a good animal model for creating human MI. Studies done on the large animals provides worth information for the researchers because of alike features of their hearts to human heart, but working with them is hard and maintenance costs are high. In comparison, using the small animals has advantages such as easy handling, less maintenance costs and high growth rate but in some of them cannot induce the natural pathogenesis of human MI. Thus, due to the high prevalence and mortality caused by MI, it is necessary consideration to creating a proper model of MI in animals and assessing the new treatment ways.
Key words: Myocardial infarction, Animal model.
