Abstract: Cardiovascular disease (CVD) has been the major cause of death worldwide for many years. Comorbidities include obesity, altered lipid profiles, and insulin resistance are frequently linked to CVD. Insulin is a crucial hormone that regulates cellular metabolism in a variety of tissues throughout the human body. Insulin resistance is distinguished by problems in glucose absorption and oxidation, a reduction in glycogen synthesis, and, to a lesser extent, the capacity to control lipid oxidation. Free fatty acids appear to be the most common substrate for ATP generation in adult myocardium, according to the literature. The purpose of this study is to address the processes that link insulin resistance to the development of cardiovascular disease. New medicines aimed at reducing insulin resistance may help to reduce both CVD and the formation of atherosclerotic plaques.