Title : Cardiophotonic resilience wavelength-driven photobiology redox signaling solar bioenergy perspectives cardiovascular health
Abstract:
Ischemic heart disease is a major cardiovascular disorder characterized by inadequate coronary perfusion, endothelial dysfunction, atherosclerotic plaque formation, thrombosis, myocardial hypoxia, and an imbalance between oxygen supply and metabolic demand. Conventional cardiovascular research primarily investigates biochemical, genetic, haemodynamic, inflammatory, and lifestyle determinants of cardiac injury, while the possible contribution of light-responsive biological processes remains comparatively under-integrated. This article proposes the interdisciplinary concept of cardiophotonic resilience, connecting cardiovascular physiology with chronobiology, electromagnetic radiation, photobiomodulation, mitochondrial redox signalling, chromophores, endogenous pigments, photosensitizers, synthetic dyes, and photogalvanic energy-conversion systems.
Insufficient or irregular daylight exposure may influence cardiovascular health indirectly through circadian desynchronisation, sleep disruption, autonomic imbalance, altered endocrine rhythms, reduced physical activity, metabolic dysregulation, and psychosocial stress. Red and near-infrared photobiomodulation may interact with cellular photoacceptors and modulate mitochondrial activity, adenosine triphosphate production, reactive oxygen species, nitric oxide signalling, inflammation, vascular tone, and endothelial function. However, these effects remain investigational and should not be confused with photosynthesis or direct solar-energy storage in human cardiac tissue.
The proposed research direction combines wavelength-resolved spectroscopy, photosensitizer screening, photochemical kinetics, electrochemical characterization, photogalvanic performance analysis, and controlled biological assays to examine the interface between light-responsive chemistry and cardiovascular physiology. It further highlights the necessity of evaluating phototoxicity, haemocompatibility, oxidative stress, tissue penetration, molecular stability, and regulatory safety before considering biomedical translation. Thus, the central proposition is not that solar energy directly powers the heart, but that precisely controlled photobiological and photochemical principles may inspire future cardiovascular monitoring, redox modulation, sustainable bioenergy platforms, and light-enabled therapeutic technologies.
This framework establishes a scientifically cautious yet innovative bridge between luminobiology, cardiometabolism, and solar photoredox engineering.
Keywords: Solar energy, Solar Bioenergy , Cardiovascular Health ,Ischemic heart disease; coronary artery disease; cardiophotonic resilience; cardiovascular photobiology; photobiomodulation.
