Biography:
The present study demonstrates that pre-operative administration of memantine in patients undergoing on-pump CABG can attenuates serum S100-B increase during cardiopulmonary bypass. Its administration is safe and no adverse effect was noted for it. It may avoid major neurological events during post-operative course by inhibiting the NMDA receptors of brain during cardiopulmonary bypass.
Title : Neuroprotective effect of memantine on serum S100-B levels after on-pump coronary artery bypass graft surgery: A randomized clinical trial