Radisson Hotel Narita
286-0221 Chiba Tomisato- shi Nakaei
650-35 Tokyo, Japan
Phone : 1 (702) 988 2320
Toll Free: 1800–883-8082
Email: cardiology@magnusmeetings.com
October 24-25, 2019 | Tokyo, Japan

B.E. Scholzel

Oral Speaker at Cardiology Conferences- B.E. Scholzel
B.E. Scholzel
Amphia Hospital, Breda, Netherlands
Title : Improve upper extremity function following transradial PCI; Slender PCI and its potential benefits – improve study

Abstract:

Transradial percutaneous coronary intervention (TRPCI) is rapidly becoming the gold standard especially in primary percutaneous coronary intervention (PCI). Results of the ARCUS trial (Effects of trAnsRadial perCUtaneouS Coronary Intervention on Upper Extremity Function) showed upper extremity dysfunction (UED) after TRPCI.
In the IMPROVE study UED following slender TRPCI using small bore catheters (5F) will be compared to standard TRPCI using regular size guiding catheters (6F) and conventional stent techniques on two-weeks, one month and 6-months clinical outcomes.
Methods:
A total of 100 patients undergoing radial PCI using small bore guiding catheters (≤5F) and slender PCI will be included in the slender TRPCI group. Patent hemostasis of the radial artery will be obtained by means of an inflatable wrist band, and a pulse oximeter and will be maintained for a maximum of 4 hours.
The historical control group consists of 500 patients that underwent standard TRPCI using regular size 6F radial sheath and 6F guiding catheters and conventional stent techniques, following non-oxygen saturation guided hemostasis.
The main study parameter is a binary score of UED after two weeks as compared to baseline. This score for UED consists of questionnaires regarding functional status of the upper extremity as well as physical examination of the upper extremity. For the primary endpoint, the slender TRPCI group will be compared to the historical control group (ARCUS trial) at two weeks of follow-up. 
The current binary primary endpoint will be compared to the similar primary endpoint variable of the historical control group using the Pearson’s chi-square test. 
Results
To this day, 50% of all inclusions and follow-up have been completed and results of the data will be presented.
We expect that with the suggested procedural changes and adjusted features that are known to have very high risk of radial artery occlusion (disparity in sheath-to-artery ratio along with non-patent hemostasis and elongated duration of compression), approximately 5% of patients will develop new significant symptoms of UED after slender TRPCI vs. 20% of patients who underwent standard TRPCI (previous interim results of the ARCUS trial).
Conclusion
Interim analysis of UED after slender TRPCI will be presented at the CWC 2019.

Audience take away:

  • To clarify if minimizing catheter size could prevent Upper Extremity Dysfunction
  • To increase awareness for Upper Extremity Dysfunction among cardiologists
  • To improve overall patient outcome: both cardiac and the upper extremity function
  • This study also proves efficiency of slender TR-PCI by preventing costs made by treating complications following conventional 6F TR-PCI

Biography:

Dr. Scholzel studied Medicine at the Erasmus University of Rotterdam in the Netherlands and graduated as an MD in 2003. He followed his cardiology training in the St. Antonius Hospital in Nieuwegein, The Netherlands. After one year fellowship in Interventional Cardiology he obtained a position as interventional cardiologist and staff member in the Amphia Hospital in Breda, the Netherlands. In 2015 he received his PhD degree at the Univerity of Utrecht, the Netherlands.